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Diagnostik und Therapie des malignen Pleuramesothelioms - von der Palliationzur kurativen Intention


Opitz, I; Weder, W (2012). Diagnostik und Therapie des malignen Pleuramesothelioms - von der Palliationzur kurativen Intention. Therapeutische Umschau. Revue thérapeutique, 69(7):401-5.

Abstract

Malignant pleural mesothelioma continues to be a clinical challenge and its incidence will continue to increase worldwide. Once diagnosed with pleural mesothelioma, patients nearly invariably die of the disease. While the benefit of chemotherapy for advanced disease has been established, many other aspects of treatment continue to be controversial, in particular in regard to surgery and radiotherapy. However, the best survival data is reported from groups using multimodality treatment including surgery for patients qualifying from a tumor stage - and functional perspective. Therefore, efforts should focus on improving staging systems. Translational studies should be included with the final aim of finding reliable markers for response to therapy. Despite both, the increase in basic biologic knowledge and the fact that many new agents have reached various stages of development, the number of new treatments that have been approved for patients has not increased. As mesothelioma is a rare disease, the number of patients is limiting and more innovative trial designs (such as multi-arm multi-stage trials [1]) using cooperative platforms to eliminate less effective treatments may be the best way forward.

Abstract

Malignant pleural mesothelioma continues to be a clinical challenge and its incidence will continue to increase worldwide. Once diagnosed with pleural mesothelioma, patients nearly invariably die of the disease. While the benefit of chemotherapy for advanced disease has been established, many other aspects of treatment continue to be controversial, in particular in regard to surgery and radiotherapy. However, the best survival data is reported from groups using multimodality treatment including surgery for patients qualifying from a tumor stage - and functional perspective. Therefore, efforts should focus on improving staging systems. Translational studies should be included with the final aim of finding reliable markers for response to therapy. Despite both, the increase in basic biologic knowledge and the fact that many new agents have reached various stages of development, the number of new treatments that have been approved for patients has not increased. As mesothelioma is a rare disease, the number of patients is limiting and more innovative trial designs (such as multi-arm multi-stage trials [1]) using cooperative platforms to eliminate less effective treatments may be the best way forward.

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Additional indexing

Other titles:Malignant pleural mesothelioma
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Thoracic Surgery
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:July 2012
Deposited On:18 Feb 2013 12:29
Last Modified:18 Aug 2016 07:19
Publisher:Hogrefe Verlag
ISSN:0040-5930
Publisher DOI:https://doi.org/10.1024/0040-5930/a000306
PubMed ID:22753288

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