Header

UZH-Logo

Maintenance Infos

Islet inflammation in type 2 diabetes: from metabolic stress to therapy


Donath, M Y; Schumann, D M; Faulenbach, M; Ellingsgaard, H; Perren, A; Ehses, J A (2008). Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Diabetes Care, 31 Sup:S161-S164.

Abstract

Decreases in both mass and secretory function of insulin-producing beta-cells contribute to the pathophysiology of type 2 diabetes. The histology of islets from patients with type 2 diabetes displays an inflammatory process characterized by the presence of cytokines, apoptotic cells, immune cell infiltration, amyloid deposits, and eventually fibrosis. This inflammatory process is probably the combined consequence of dyslipidemia, hyperglycemia, and increased circulating adipokines. Therefore, modulation of intra-islet inflammatory mediators, in particular interleukin-1 beta, appears as a promising therapeutic approach.

Abstract

Decreases in both mass and secretory function of insulin-producing beta-cells contribute to the pathophysiology of type 2 diabetes. The histology of islets from patients with type 2 diabetes displays an inflammatory process characterized by the presence of cytokines, apoptotic cells, immune cell infiltration, amyloid deposits, and eventually fibrosis. This inflammatory process is probably the combined consequence of dyslipidemia, hyperglycemia, and increased circulating adipokines. Therefore, modulation of intra-islet inflammatory mediators, in particular interleukin-1 beta, appears as a promising therapeutic approach.

Statistics

Citations

Dimensions.ai Metrics
185 citations in Web of Science®
208 citations in Scopus®
310 citations in Microsoft Academic
Google Scholar™

Altmetrics

Downloads

3 downloads since deposited on 05 Jan 2009
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
Dewey Decimal Classification:610 Medicine & health
Date:2008
Deposited On:05 Jan 2009 11:07
Last Modified:18 Feb 2018 10:02
Publisher:American Diabetes Association
ISSN:0149-5992
OA Status:Closed
Publisher DOI:https://doi.org/10.2337/dc08-s243
PubMed ID:18227479

Download