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Cytokines and beta-cell biology: from concept to clinical translation


Donath, M Y; Størling, J; Berchtold, L A; Billestrup, N; Mandrup-Poulsen, T (2008). Cytokines and beta-cell biology: from concept to clinical translation. Endocrine Reviews, 29(3):334-350.

Abstract

The tale of cytokines and the beta-cell is a long story, starting with in vitro discovery in 1984, evolving via descriptive and phenomenological studies to detailed mapping of the signalling pathways, gene- and protein expression patterns, molecular and biochemical effector mechanisms to in vivo studies in spontaneously diabetic and transgenic animal models. Only very recently have steps been taken to translate the accumulating compelling preclinical data into clinical trials. The aim of this chapter is to present an overview of early and recent key observations from our own groups as well as other laboratories that serve to illuminate the road from concept to clinical translation.

Abstract

The tale of cytokines and the beta-cell is a long story, starting with in vitro discovery in 1984, evolving via descriptive and phenomenological studies to detailed mapping of the signalling pathways, gene- and protein expression patterns, molecular and biochemical effector mechanisms to in vivo studies in spontaneously diabetic and transgenic animal models. Only very recently have steps been taken to translate the accumulating compelling preclinical data into clinical trials. The aim of this chapter is to present an overview of early and recent key observations from our own groups as well as other laboratories that serve to illuminate the road from concept to clinical translation.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2008
Deposited On:05 Jan 2009 11:16
Last Modified:21 Nov 2017 13:42
Publisher:Endocrine Society
ISSN:0163-769X
Publisher DOI:https://doi.org/10.1210/er.2007-0033
PubMed ID:18048762

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