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A mechanism for eye position effects on spontaneous nystagmus


Khojasteh, Elham; Bockisch, Christopher J; Straumann, Dominik; Hegemann, Stefan C A (2012). A mechanism for eye position effects on spontaneous nystagmus. In: 34th Annual Internat. Conference of the IEEE Engineering in Medicin and Biology Society, San Diego, USA, August 2012 - August 2012, 3572-5.

Abstract

In acute stages of unilateral vestibular deficit, the imbalanced tonic activity on vestibular afferents evokes spontaneous nystagmus. The slow-phase velocity of this nystagmus varies with eye position, such that it is smaller when looking in the direction of slow-phases. The neural mechanism for this behavior is still not understood. Here, using a simple control system model, we show that plausible changes in the neural responses within the central vestibulo-ocular reflex pathway are adequate to cause eye position dependent effects in the nystagmus pattern. The proposed transformations in population response functions could happen immediately following a lesion and can be useful to stabilize gaze in part of the gaze field.

Abstract

In acute stages of unilateral vestibular deficit, the imbalanced tonic activity on vestibular afferents evokes spontaneous nystagmus. The slow-phase velocity of this nystagmus varies with eye position, such that it is smaller when looking in the direction of slow-phases. The neural mechanism for this behavior is still not understood. Here, using a simple control system model, we show that plausible changes in the neural responses within the central vestibulo-ocular reflex pathway are adequate to cause eye position dependent effects in the nystagmus pattern. The proposed transformations in population response functions could happen immediately following a lesion and can be useful to stabilize gaze in part of the gaze field.

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Additional indexing

Item Type:Conference or Workshop Item (Paper), not refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
Dewey Decimal Classification:610 Medicine & health
Language:English
Event End Date:August 2012
Deposited On:19 Feb 2013 11:59
Last Modified:05 Aug 2017 20:44
Publisher:Insti
ISSN:1557-170X
Publisher DOI:https://doi.org/10.1109/EMBC.2012.6346738
PubMed ID:23366699

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