Header

UZH-Logo

Maintenance Infos

Alle Medikamente zum Frühstück? - Einfluss der Nahrung auf die Medikamentenwirkung


Corti, N; Taegtmeyer, A B (2012). Alle Medikamente zum Frühstück? - Einfluss der Nahrung auf die Medikamentenwirkung. Praxis, 101(13):849-55.

Abstract

Most medicines are taken with breakfast which is usually unproblematic and has the advantage of improving adherence through establishment of a daily routine. However, due to alterations in absorption from the gastrointestinal tract, there are a number of medicines that either lose (such as bisphosphonates) or gain (such as albendazole) efficacy if taken together with food. Food components can also affect drug-metabolising enzymes and even cause drug toxicity (alcohol and grapefruit juice are notable examples). Conversely, drugs such as monoamine oxidase inhibitors can inhibit the metabolism of tyramine in tyramine-rich foods and lead to adverse circulatory reactions. These and other examples of when the ingestion of medication together with food can cause clinically relevant problems are discussed in this article.

Abstract

Most medicines are taken with breakfast which is usually unproblematic and has the advantage of improving adherence through establishment of a daily routine. However, due to alterations in absorption from the gastrointestinal tract, there are a number of medicines that either lose (such as bisphosphonates) or gain (such as albendazole) efficacy if taken together with food. Food components can also affect drug-metabolising enzymes and even cause drug toxicity (alcohol and grapefruit juice are notable examples). Conversely, drugs such as monoamine oxidase inhibitors can inhibit the metabolism of tyramine in tyramine-rich foods and lead to adverse circulatory reactions. These and other examples of when the ingestion of medication together with food can cause clinically relevant problems are discussed in this article.

Statistics

Citations

Altmetrics

Downloads

1 download since deposited on 07 Mar 2013
0 downloads since 12 months
Detailed statistics

Additional indexing

Other titles:Clinically important food-drug interactions: what the practitioner needs to know
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:2012
Deposited On:07 Mar 2013 10:18
Last Modified:05 Apr 2016 16:37
Publisher:Hans Huber
ISSN:1661-8157
Publisher DOI:https://doi.org/10.1024/1661-8157/a000978
PubMed ID:22715076

Download

Preview Icon on Download
Content: Published Version
Language: German
Filetype: PDF - Registered users only
Size: 128kB
View at publisher