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Electrical and mechanical ventricular activation during left bundle branch block and resynchronization


Strik, Marc; Regoli, François; Auricchio, Angelo; Prinzen, Frits (2012). Electrical and mechanical ventricular activation during left bundle branch block and resynchronization. Journal of cardiovascular translational research, 5(2):117-126.

Abstract

Cardiac resynchronization therapy (CRT) aims to treat selected heart failure patients suffering from conduction abnormalities with left bundle branch block (LBBB) as the culprit disease. LBBB remained largely underinvestigated until it became apparent that the amount of response to CRT was heterogeneous and that the therapy and underlying pathology were thus incompletely understood. In this review, current knowledge concerning activation in LBBB and during biventricular pacing will be explored and applied to current CRT practice, highlighting novel ways to better measure and treat the electrical substrate.

Abstract

Cardiac resynchronization therapy (CRT) aims to treat selected heart failure patients suffering from conduction abnormalities with left bundle branch block (LBBB) as the culprit disease. LBBB remained largely underinvestigated until it became apparent that the amount of response to CRT was heterogeneous and that the therapy and underlying pathology were thus incompletely understood. In this review, current knowledge concerning activation in LBBB and during biventricular pacing will be explored and applied to current CRT practice, highlighting novel ways to better measure and treat the electrical substrate.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Cardiocentro Ticino
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:01 Mar 2013 08:20
Last Modified:07 Dec 2017 20:25
Publisher:Springer
ISSN:1937-5387
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1007/s12265-012-9351-1
PubMed ID:22311563

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