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"Vitamin D - why does it matter?" - defining vitamin D deficiency and its prevalence


Bischoff-Ferrari, Heike A (2012). "Vitamin D - why does it matter?" - defining vitamin D deficiency and its prevalence. Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum, 243:3-6.

Abstract

Vitamin D deficiency is prevalent in about 50 % of adults and limited data support a similar prevalence in children. This is of concern, as vitamin D deficiency is a risk factor for falls and fractures and several double-blind RCTs provide evidence that supplementation reduces the risk of fall and fractures among the senior population. Further, large epidemiologic studies consistently report that vitamin D deficiency confers an increased risk of mortality, cardiovascular disease and cancer, especially colo-rectal cancer. However, as large clinical trials for non-musculoskeletal endpoints are missing today, public health recommendations are based primarily on bone health to argue vitamin D repletion in the population.

Abstract

Vitamin D deficiency is prevalent in about 50 % of adults and limited data support a similar prevalence in children. This is of concern, as vitamin D deficiency is a risk factor for falls and fractures and several double-blind RCTs provide evidence that supplementation reduces the risk of fall and fractures among the senior population. Further, large epidemiologic studies consistently report that vitamin D deficiency confers an increased risk of mortality, cardiovascular disease and cancer, especially colo-rectal cancer. However, as large clinical trials for non-musculoskeletal endpoints are missing today, public health recommendations are based primarily on bone health to argue vitamin D repletion in the population.

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11 citations in Web of Science®
18 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Geriatric Medicine
Dewey Decimal Classification:360 Social problems & social services
300 Social sciences, sociology & anthropology
Language:English
Date:2012
Deposited On:28 Feb 2013 09:32
Last Modified:05 Apr 2016 16:39
Publisher:Wiley-Blackwell
ISSN:0085-591X
Publisher DOI:https://doi.org/10.3109/00365513.2012.681938
PubMed ID:22536756

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