Header

UZH-Logo

Maintenance Infos

Topical therapies in inflammatory bowel disease


Frei, Pascal; Biedermann, Luc; Manser, Christine N; Wilk, Maike; Manz, Michael; Vavricka, Stephan R; Rogler, Gerhard (2012). Topical therapies in inflammatory bowel disease. Digestion, 86(Suppl. 1):36-44.

Abstract

Due to misunderstandings about their effectiveness and feasibility, topical (or rectal) therapies with aminosalicylates (5-aminosalicylic acid, 5-ASA) and steroids are often underused in patients with ulcerative colitis (UC). However, many of these patients could be treated solely with rectal/topical therapies, or could benefit from them in combination with oral therapies. We review the evidence for topical therapies containing 5-ASA and budesonide in UC and discuss how these therapies can be optimized in daily practice, thereby improving compliance. Finally, we provide a brief summary of studies on the use of other topical treatments in UC, the results of which were both promising and negative.

Abstract

Due to misunderstandings about their effectiveness and feasibility, topical (or rectal) therapies with aminosalicylates (5-aminosalicylic acid, 5-ASA) and steroids are often underused in patients with ulcerative colitis (UC). However, many of these patients could be treated solely with rectal/topical therapies, or could benefit from them in combination with oral therapies. We review the evidence for topical therapies containing 5-ASA and budesonide in UC and discuss how these therapies can be optimized in daily practice, thereby improving compliance. Finally, we provide a brief summary of studies on the use of other topical treatments in UC, the results of which were both promising and negative.

Statistics

Citations

8 citations in Web of Science®
10 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 13 Mar 2013
44 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:13 Mar 2013 13:59
Last Modified:07 Dec 2017 20:35
Publisher:Karger
ISSN:0012-2823
Publisher DOI:https://doi.org/10.1159/000341947
PubMed ID:23051725

Download

Download PDF  'Topical therapies in inflammatory bowel disease'.
Preview
Content: Accepted Version
Filetype: PDF
Size: 107kB
View at publisher