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Lichtblicke beim schwarzen Hautkrebs aus der Sicht von Pathologen


Mihic-Probst, D; Beer, M (2013). Lichtblicke beim schwarzen Hautkrebs aus der Sicht von Pathologen. Praxis, 102(4):219-224.

Abstract

Malignant melanoma is the most common cause of death from skin cancer. Wide surgical excision of localized melanoma in its primary stages remains the main curative therapy. Identifying patients at an early tumour stage is therefore one of the most significant steps for treatment. In the last decades, molecular pathology rapidly established itself in melanoma research. We present new molecular methods, their significance and their application, especially focusing on BRAF( V600) mutation and BRAF-inhibiting tumor targeting therapy. Resistance to tumor targeting therapies and cell line experiments, which have evidenced a sub population with stem cell properties, illustrate melanoma heterogeneity. Efforts to develop drugs that target more than a single target gene are currently underway.

Abstract

Malignant melanoma is the most common cause of death from skin cancer. Wide surgical excision of localized melanoma in its primary stages remains the main curative therapy. Identifying patients at an early tumour stage is therefore one of the most significant steps for treatment. In the last decades, molecular pathology rapidly established itself in melanoma research. We present new molecular methods, their significance and their application, especially focusing on BRAF( V600) mutation and BRAF-inhibiting tumor targeting therapy. Resistance to tumor targeting therapies and cell line experiments, which have evidenced a sub population with stem cell properties, illustrate melanoma heterogeneity. Efforts to develop drugs that target more than a single target gene are currently underway.

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Additional indexing

Other titles:Insights into melanoma from a pathologist's perspective
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:2013
Deposited On:23 May 2013 13:06
Last Modified:07 Dec 2017 21:13
Publisher:Hans Huber
ISSN:1661-8157
Publisher DOI:https://doi.org/10.1024/1661-8157/a001190
PubMed ID:23399605

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