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Methylphenidate enhances neural stem cell differentiation


Bartl, Jasmin; Mori, Takatoshi; Riederer, Peter; Ozawa, Hiroki; Grünblatt, Edna (2013). Methylphenidate enhances neural stem cell differentiation. Journal of Molecular Psychiatry, 1:5.

Abstract

Background: The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins at a time when the brain is still developing and the long-term consequences of MPH are still not fully clarified, we examined the influences of an acute treatment with MPH on the differentiation and proliferation of murine neural stem cells (mNSC). Findings and conclusion We found that MPH enhanced neuronal differentiation and inhibited neural proliferation.

Abstract

Background: The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins at a time when the brain is still developing and the long-term consequences of MPH are still not fully clarified, we examined the influences of an acute treatment with MPH on the differentiation and proliferation of murine neural stem cells (mNSC). Findings and conclusion We found that MPH enhanced neuronal differentiation and inhibited neural proliferation.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Center for Child and Adolescent Psychiatry
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:05 Jun 2013 15:25
Last Modified:07 Dec 2017 21:17
Publisher:Biomed Central
ISSN:2049-9256
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1186/2049-9256-1-5
PubMed ID:25408898

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