Header

UZH-Logo

Maintenance Infos

Pulmonary involvement in Fabry disease: Overview and perspectives


Franzen, Daniel; Krayenbuehl, Pierre A; Lidove, Olivier; Aubert, John-David; Barbey, Frederic (2013). Pulmonary involvement in Fabry disease: Overview and perspectives. European Journal of Internal Medicine, 24(8):707-713.

Abstract

Fabry disease (FD) is an X-linked lysosomal storage disorder caused by deficiency of alpha-galactosidase A, which leads to storage of sphingolipids in virtually all human cells and consequently to organ dysfunction. Pulmonary involvement is still debated. But, obstructive lung disease is up to ten times more prevalent in patients with FD compared to general public. Also, an accelerated decline in forced expiratory volume in one second (FEV1) over time was observed in these patients. Lysosomal storage of glycosphingolipids is considered leading to small airway disease via hyperplasia of the bronchiolar smooth muscle cells. Larger airways may become involved with ongoing disease process. There is no evidence for involvement of the lung interstitium in FD. The effect of enzyme replacement therapy on respiratory involvement remains to be determined in large, prospective controlled trials.

Abstract

Fabry disease (FD) is an X-linked lysosomal storage disorder caused by deficiency of alpha-galactosidase A, which leads to storage of sphingolipids in virtually all human cells and consequently to organ dysfunction. Pulmonary involvement is still debated. But, obstructive lung disease is up to ten times more prevalent in patients with FD compared to general public. Also, an accelerated decline in forced expiratory volume in one second (FEV1) over time was observed in these patients. Lysosomal storage of glycosphingolipids is considered leading to small airway disease via hyperplasia of the bronchiolar smooth muscle cells. Larger airways may become involved with ongoing disease process. There is no evidence for involvement of the lung interstitium in FD. The effect of enzyme replacement therapy on respiratory involvement remains to be determined in large, prospective controlled trials.

Statistics

Citations

Dimensions.ai Metrics
11 citations in Web of Science®
9 citations in Scopus®
14 citations in Microsoft Academic
Google Scholar™

Altmetrics

Downloads

178 downloads since deposited on 11 Jun 2013
20 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Pneumology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:11 Jun 2013 11:47
Last Modified:16 Feb 2018 17:48
Publisher:Elsevier
ISSN:0953-6205
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.ejim.2013.05.003
PubMed ID:23726861

Download

Download PDF  'Pulmonary involvement in Fabry disease: Overview and perspectives'.
Preview
Content: Accepted Version
Filetype: PDF
Size: 113kB