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Comparison of ultrasonography and histologic examination for identification of ocular diseases of animals: 113 cases (2000–2010)


Gallhöfer, N S; Bentley, E; Ruetten, M; Grest, P; Hässig, M; Kircher, P R; Dubielzig, R R; Spiess, B M; Pot, S A (2013). Comparison of ultrasonography and histologic examination for identification of ocular diseases of animals: 113 cases (2000–2010). Journal of the American Veterinary Medical Association, 243(3):376-388.

Abstract

Objective—To compare ultrasonographic and histologic examination findings for eyes of animals with ocular diseases. Design—Retrospective study. Animals—116 eyes of 113 animals examined at 2 facilities. Procedures—Diseased eyes of animals were examined by means of ultrasonography, re- moved via enucleation or exenteration, then histologically examined. Ultrasonographic im- ages and histopathologic slides were evaluated, and diseases of eyes were identified with each of those methods and allocated to various categories. For each disease category, agreement between results of ultrasonography and those of histologic examination was assessed via determination of κ statistic values. Results—Tests had good agreement for identification of iris or ciliary body neoplasia. Over- all, intraocular neoplasia was not detected via ultrasonography for only 2 of 31 eyes with histologically detected neoplasia. Hemorrhagic or inflammatory changes were misinter- preted as neoplasia for 8 of 37 (22%) eyes. Tests had moderate to acceptable agreement for identification of retinal detachment. Retinal detachment was not detected by means of ultrasonography for 14 of 38 (37%) eyes with that diagnosis determined via histologic examination at one of the facilities (primarily in eyes with intraocular hemorrhage); however, retinal detachment was not identified via histologic examination for 6 of 38 (16%) eyes with that diagnosis determined via ultrasonography at the other facility. Conclusions and Clinical Relevance—Agreement between tests evaluated in this study was clinically satisfactory for identification of intraocular neoplasia. Typically, diseases were misdiagnosed via ultrasonography for eyes with poor image contrast. Because determina- tion of ultrasonographic diagnoses of retinal detachment and intraocular neoplasm may be of prognostic importance, performance of additional ultrasonographic techniques may be indicated.

Abstract

Objective—To compare ultrasonographic and histologic examination findings for eyes of animals with ocular diseases. Design—Retrospective study. Animals—116 eyes of 113 animals examined at 2 facilities. Procedures—Diseased eyes of animals were examined by means of ultrasonography, re- moved via enucleation or exenteration, then histologically examined. Ultrasonographic im- ages and histopathologic slides were evaluated, and diseases of eyes were identified with each of those methods and allocated to various categories. For each disease category, agreement between results of ultrasonography and those of histologic examination was assessed via determination of κ statistic values. Results—Tests had good agreement for identification of iris or ciliary body neoplasia. Over- all, intraocular neoplasia was not detected via ultrasonography for only 2 of 31 eyes with histologically detected neoplasia. Hemorrhagic or inflammatory changes were misinter- preted as neoplasia for 8 of 37 (22%) eyes. Tests had moderate to acceptable agreement for identification of retinal detachment. Retinal detachment was not detected by means of ultrasonography for 14 of 38 (37%) eyes with that diagnosis determined via histologic examination at one of the facilities (primarily in eyes with intraocular hemorrhage); however, retinal detachment was not identified via histologic examination for 6 of 38 (16%) eyes with that diagnosis determined via ultrasonography at the other facility. Conclusions and Clinical Relevance—Agreement between tests evaluated in this study was clinically satisfactory for identification of intraocular neoplasia. Typically, diseases were misdiagnosed via ultrasonography for eyes with poor image contrast. Because determina- tion of ultrasonographic diagnoses of retinal detachment and intraocular neoplasm may be of prognostic importance, performance of additional ultrasonographic techniques may be indicated.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
05 Vetsuisse Faculty > Veterinary Clinic > Equine Department
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:August 2013
Deposited On:20 Jun 2013 06:56
Last Modified:05 Apr 2016 16:49
Publisher:American Veterinary Medical Association
ISSN:0003-1488
Publisher DOI:https://doi.org/10.2460/javma.243.3.376
PubMed ID:23865880

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