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Live Mammalian Cell Arrays


Woodruff, Kristina; Fidalgo, Luis M; Gobaa, Samy; Lutolf, Matthias P; Maerkl, Sebastian J (2013). Live Mammalian Cell Arrays. Nature Methods, 10(6):550-552.

Abstract

High-content assays have the potential to drastically increase throughput in cell biology and drug discovery, but handling and culturing large libraries of cells such as primary tumor or cancer cell lines requires expensive, dedicated robotic equipment. We have developed a simple, yet powerful method that uses contact spotting to generate highdensity nanowell arrays of live mammalian cells for the culture and interrogation of cell libraries.

Abstract

High-content assays have the potential to drastically increase throughput in cell biology and drug discovery, but handling and culturing large libraries of cells such as primary tumor or cancer cell lines requires expensive, dedicated robotic equipment. We have developed a simple, yet powerful method that uses contact spotting to generate highdensity nanowell arrays of live mammalian cells for the culture and interrogation of cell libraries.

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12 citations in Web of Science®
9 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:Special Collections > SystemsX.ch
Special Collections > SystemsX.ch > Research, Technology and Development Projects > DynamiX
Special Collections > SystemsX.ch > Research, Technology and Development Projects
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:June 2013
Deposited On:22 Jun 2013 13:32
Last Modified:05 Apr 2016 16:49
Publisher:Nature Publishing Group
ISSN:1548-7091
Publisher DOI:https://doi.org/10.1038/NMETH.2473

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