Header

UZH-Logo

Maintenance Infos

The effect of venous and arterial occlusion of the arm on changes in tissue hemodynamics, oxygenation, and ultra-weak photon emission


Scholkmann, Felix; Schraa, Olaf; van Wijk, Roeland; Wolf, Martin (2013). The effect of venous and arterial occlusion of the arm on changes in tissue hemodynamics, oxygenation, and ultra-weak photon emission. In: Welch, William J; Palm, Fredrik; Bruley, Duane F; Harrison, David K. Oxygen Transport to Tissue XXXIV. New York: Springer, 257-64.

Abstract

Ultra-weak photon emission (UPE) is a general feature of living -biological systems. To gain further insights into the origin of UPE and its physiological significance, the aim of the present study was to investigate the connection between hemodynamics (HD), oxygenation (OX), and UPE. Therefore, during venous and arterial occlusion (VO, AO), changes of UPE and surrogates of HD as well as OX were measured simultaneously using two photomultipliers and near-infrared spectroscopy, respectively. We showed that (1) changes in UPE correlate significantly nonlinearly with changes in oxyhemoglobin (Δ[O(2)Hb]), deoxyhemoglobin (Δ[HHb]), and hemoglobin difference (Δ[HbD] = Δ[O(2)Hb]-Δ[HHb]), indicating a complex association between UPE and tissue HD/OX; (2) UPE decreases significantly during AO but not during VO; (3) UPE increases significantly after AO; and (4) the view that ROS are the source of UPE is generally supported by the present study, although some findings remain unexplained in the context of the theory of ROS-mediated UPE generation. In conclusion, the present study revealed new insights into the interplay between HD, OX, and UPE and opens up new questions that have to be addressed by future studies.

Abstract

Ultra-weak photon emission (UPE) is a general feature of living -biological systems. To gain further insights into the origin of UPE and its physiological significance, the aim of the present study was to investigate the connection between hemodynamics (HD), oxygenation (OX), and UPE. Therefore, during venous and arterial occlusion (VO, AO), changes of UPE and surrogates of HD as well as OX were measured simultaneously using two photomultipliers and near-infrared spectroscopy, respectively. We showed that (1) changes in UPE correlate significantly nonlinearly with changes in oxyhemoglobin (Δ[O(2)Hb]), deoxyhemoglobin (Δ[HHb]), and hemoglobin difference (Δ[HbD] = Δ[O(2)Hb]-Δ[HHb]), indicating a complex association between UPE and tissue HD/OX; (2) UPE decreases significantly during AO but not during VO; (3) UPE increases significantly after AO; and (4) the view that ROS are the source of UPE is generally supported by the present study, although some findings remain unexplained in the context of the theory of ROS-mediated UPE generation. In conclusion, the present study revealed new insights into the interplay between HD, OX, and UPE and opens up new questions that have to be addressed by future studies.

Statistics

Citations

1 citation in Web of Science®
2 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

105 downloads since deposited on 30 Jul 2013
68 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:30 Jul 2013 12:14
Last Modified:05 Apr 2016 16:53
Publisher:Springer
Series Name:Advances in Experimental Medicine and Biology
Number:765
ISSN:0065-2598
ISBN:978-1-4614-4989-8
Additional Information:The final publication is available at link.springer.com
Publisher DOI:https://doi.org/10.1007/978-1-4614-4989-8_36
PubMed ID:22879042

Download

Preview Icon on Download
Content: Published Version
Filetype: PDF - Registered users only
Size: 591kB
View at publisher
Preview Icon on Download
Preview
Content: Accepted Version
Filetype: PDF
Size: 869kB

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations