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Survival time and prognostic factors in cats with newly diagnosed diabetes mellitus: 114 cases (2000-2009)


Callegari, C; Mercuriali, E; Hafner, M; Coppola, L M; Guazzetti, S; Lutz, T A; Reusch, C E; Zini, E (2013). Survival time and prognostic factors in cats with newly diagnosed diabetes mellitus: 114 cases (2000-2009). Journal of the American Veterinary Medical Association, 243(1):91-95.

Abstract

OBJECTIVE: To determine overall survival time and identify prognostic factors associated with survival time in cats with newly diagnosed diabetes mellitus. DESIGN: Retrospective case series. ANIMALS: 114 cats with newly diagnosed diabetes mellitus. PROCEDURES: Data for analysis included history, signalment, physical examination findings, hematologic and serum biochemical data, presence of ketoacidosis, and diagnosis of concurrent diseases at initial evaluation. The effects of possible predictors on survival time were determined by calculating hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: Median survival time of diabetic cats was 516 days (range, 1 to 3,468 days); 70%, 64%, and 46% lived longer than 3, 6, and 24 months, respectively. Survival time was significantly shorter for cats with higher creatinine concentrations, with a hazard of dying approximately 5% greater for each increase of 10 μg/dL in serum creatinine concentration (adjusted HR, 1.005; 95% CI, 1.003 to 1.007). Ketoacidosis was not significantly associated with survival time (HR, 1.02; 95% CI, 0.590 to 1.78). CONCLUSIONS AND CLINICAL RELEVANCE: Cats with newly diagnosed diabetes mellitus had a fair to good prognosis. High serum creatinine concentration at diagnosis was associated with a poor outcome, likely because of the adverse effects of renal dysfunction. Ketoacidosis apparently was not associated with decreased survival time, suggesting that this complication should not necessarily be regarded as unfavorable.

Abstract

OBJECTIVE: To determine overall survival time and identify prognostic factors associated with survival time in cats with newly diagnosed diabetes mellitus. DESIGN: Retrospective case series. ANIMALS: 114 cats with newly diagnosed diabetes mellitus. PROCEDURES: Data for analysis included history, signalment, physical examination findings, hematologic and serum biochemical data, presence of ketoacidosis, and diagnosis of concurrent diseases at initial evaluation. The effects of possible predictors on survival time were determined by calculating hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: Median survival time of diabetic cats was 516 days (range, 1 to 3,468 days); 70%, 64%, and 46% lived longer than 3, 6, and 24 months, respectively. Survival time was significantly shorter for cats with higher creatinine concentrations, with a hazard of dying approximately 5% greater for each increase of 10 μg/dL in serum creatinine concentration (adjusted HR, 1.005; 95% CI, 1.003 to 1.007). Ketoacidosis was not significantly associated with survival time (HR, 1.02; 95% CI, 0.590 to 1.78). CONCLUSIONS AND CLINICAL RELEVANCE: Cats with newly diagnosed diabetes mellitus had a fair to good prognosis. High serum creatinine concentration at diagnosis was associated with a poor outcome, likely because of the adverse effects of renal dysfunction. Ketoacidosis apparently was not associated with decreased survival time, suggesting that this complication should not necessarily be regarded as unfavorable.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2013
Deposited On:26 Aug 2013 10:55
Last Modified:05 Apr 2016 16:53
Publisher:American Veterinary Medical Association
ISSN:0003-1488
Publisher DOI:https://doi.org/10.2460/javma.243.1.91
PubMed ID:23786195

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