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Binding Interaction of [Re(H2O)3(CO)3]+ with the DNA Fragment d(CpGpG)


Zobi, F; Blacque, O; Sigel, Roland K O; Alberto, R (2007). Binding Interaction of [Re(H2O)3(CO)3]+ with the DNA Fragment d(CpGpG). Inorganic Chemistry, 46(25):10458-10460.

Abstract

Insights into the interaction of the [Re(H2O)3(CO)3]+ complex (1) with the DNA fragment d(CpGpG) have been obtained by one- (1D) and two-dimensional (2D) NMR spectroscopy. The H8 resonances of the single major [Re(H2O)d(CpGpG)(CO)3]– adduct (2) exhibit pH-independent chemical shift changes attributable to metal N7 binding. The structure of this adduct has been characterized by molecular modeling studies based on 1D and 2D NMR data. In solution, 2 shows the presence of two N7-coordinated guanine moieties in a head-to-head (HH) orientation as evidenced by G2H8/G3H8 cross peaks in the [1H-1H]-NOESY spectrum. The presence of the 5'-bridging phosphodiester appears to stabilize the HH1 L conformer as previously described for related Pt and Rh complexes.

Abstract

Insights into the interaction of the [Re(H2O)3(CO)3]+ complex (1) with the DNA fragment d(CpGpG) have been obtained by one- (1D) and two-dimensional (2D) NMR spectroscopy. The H8 resonances of the single major [Re(H2O)d(CpGpG)(CO)3]– adduct (2) exhibit pH-independent chemical shift changes attributable to metal N7 binding. The structure of this adduct has been characterized by molecular modeling studies based on 1D and 2D NMR data. In solution, 2 shows the presence of two N7-coordinated guanine moieties in a head-to-head (HH) orientation as evidenced by G2H8/G3H8 cross peaks in the [1H-1H]-NOESY spectrum. The presence of the 5'-bridging phosphodiester appears to stabilize the HH1 L conformer as previously described for related Pt and Rh complexes.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:November 2007
Deposited On:08 Aug 2013 07:49
Last Modified:18 May 2017 08:03
Publisher:American Chemical Society
ISSN:0020-1669
Publisher DOI:https://doi.org/10.1021/ic701647m

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