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JCV granule cell neuronopathy and GCN-IRIS under natalizumab treatment


Schippling, S; Kempf, C; Büchele, F; Jelcic, I; Bozinov, O; Bont, A; Linnebank, M; Sospedra, M; Weller, M; Budka, H; Martin, R (2013). JCV granule cell neuronopathy and GCN-IRIS under natalizumab treatment. Annals of Neurology, 74(4):622-626.

Abstract

Progressive multifocal leukoencephalopathy (PML) is the most common clinical presentation of JC virus-associated CNS disease and has emerged as a major safety concern in multiple sclerosis patients treated with the monoclonal antibody natalizumab. Here we report clinical, radiological and histological findings of a case of cerebellar granule cell neuronopathy (GCN), a JCV-associated CNS disease, so far unreported amongst patients treated with natalizumab. GCN should be considered as a JCV CNS manifestation in patients with newly developed, progressive cerebellar signs under treatment with natalizumab, especially in cases where cerebellar atrophy can be visualized by MRI. ANN NEUROL 2013. © 2013 American Neurological Association.

Abstract

Progressive multifocal leukoencephalopathy (PML) is the most common clinical presentation of JC virus-associated CNS disease and has emerged as a major safety concern in multiple sclerosis patients treated with the monoclonal antibody natalizumab. Here we report clinical, radiological and histological findings of a case of cerebellar granule cell neuronopathy (GCN), a JCV-associated CNS disease, so far unreported amongst patients treated with natalizumab. GCN should be considered as a JCV CNS manifestation in patients with newly developed, progressive cerebellar signs under treatment with natalizumab, especially in cases where cerebellar atrophy can be visualized by MRI. ANN NEUROL 2013. © 2013 American Neurological Association.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2013
Deposited On:22 Aug 2013 06:30
Last Modified:05 Apr 2016 16:54
Publisher:Wiley-Blackwell
ISSN:0364-5134
Publisher DOI:https://doi.org/10.1002/ana.23973
PubMed ID:23868420

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