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Das Nationale Forschungsprogramm 1A: Eine gemeindeorientierte Interventionsstudie. Methodische Überlegungen zu verschiedenen Studientypen


Gutzwiller, Felix (1980). Das Nationale Forschungsprogramm 1A: Eine gemeindeorientierte Interventionsstudie. Methodische Überlegungen zu verschiedenen Studientypen. Sozial- und Präventivmedizin, 25(5):244-249.

Abstract

Intervention tricals can principally be classified into community or clinically oriented designs. The clinical approach of the randomized controlled trial (RCT) implies the individual randomization of a volunteer population into a study and a control group. In community-oriented trials, however, the study and control group are not composed of individuals, but rather of total population groups (e.g. communities, factories). The paper gives first an overview over the historial development of epidemiological methods as the basis for both study types. Shortcomings and advantages both of RCT's and of community trials are discussed, using the examples of the "diet-heart" hypothesis and of the National Research Program 1A design, respectively. The two study types uses as primary endpoints for the analysis changes in risk factor distribution, morbidity and/or mortality. A recent alternative is presented, too: advances in angiography allow direct measurements of changes in vessels with atherosclerotic disease. The different study types available complement one another in trying to understand the mechanisms involved in disease of multifactorial origin.

Abstract

Intervention tricals can principally be classified into community or clinically oriented designs. The clinical approach of the randomized controlled trial (RCT) implies the individual randomization of a volunteer population into a study and a control group. In community-oriented trials, however, the study and control group are not composed of individuals, but rather of total population groups (e.g. communities, factories). The paper gives first an overview over the historial development of epidemiological methods as the basis for both study types. Shortcomings and advantages both of RCT's and of community trials are discussed, using the examples of the "diet-heart" hypothesis and of the National Research Program 1A design, respectively. The two study types uses as primary endpoints for the analysis changes in risk factor distribution, morbidity and/or mortality. A recent alternative is presented, too: advances in angiography allow direct measurements of changes in vessels with atherosclerotic disease. The different study types available complement one another in trying to understand the mechanisms involved in disease of multifactorial origin.

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Additional indexing

Other titles:The National Research Program 1A: a community-oriented intervention study. Methodological considerations on various types of studies
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:1980
Deposited On:14 Aug 2013 12:23
Last Modified:05 Apr 2016 16:54
Publisher:Springer
ISSN:0303-8408
Publisher DOI:https://doi.org/10.1007/BF02078489
PubMed ID:7006252

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