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Prospective audit of exudative age-related macular degeneration: 12-month outcomes in treatment-naive eyes


Gillies, M C; Walton, R; Simpson, J M; Arnold, J; Guymer, R H; McAllister, I L; Hunyor, A P; Essex, R W; Morlet, N; Barthelmes, D (2013). Prospective audit of exudative age-related macular degeneration: 12-month outcomes in treatment-naive eyes. Investigative Ophthalmology & Visual Science [IOVS], 54(8):5754-5760.

Abstract

Purpose: To report the 12-month outcomes of 1,140 treatment-naïve eyes with exudative age-related macular degeneration (wet AMD) who were treated for 12 months with intravitreal anti-VEGF drugs in routine clinical practice. Methods: Index visit characteristics, such as lesion type and size, visual acuity (VA in logMAR [Logarithm of the Minimal Angle of Resolution] letters), as well as treatments, outcomes (VA, lesion activity status) and ocular adverse events were recorded in a prospectively designed electronic database. Index visit characteristics associated with the 12-month VA outcome were identified using mixed effects linear regression. Results: Mean change in VA in the cohort after 12 months was +4.7 logMAR letters (95%CI: 3.4 to 6.1) with a mean of 7.0 injections. No significant difference was found in change in VA or number of injections by type or size of the lesion. Median time to inactivation of lesions was 194 days. VA at the index visit was the strongest predictor for the 12-month outcomes. Infectious endophthalmitis occurred in 2 cases, retinal detachment in 1 case from a total of 9,162 injections. Conclusions: These findings indicate that VEGF inhibitors can achieve reasonably good outcomes for wet AMD when used in routine clinical practice.

Abstract

Purpose: To report the 12-month outcomes of 1,140 treatment-naïve eyes with exudative age-related macular degeneration (wet AMD) who were treated for 12 months with intravitreal anti-VEGF drugs in routine clinical practice. Methods: Index visit characteristics, such as lesion type and size, visual acuity (VA in logMAR [Logarithm of the Minimal Angle of Resolution] letters), as well as treatments, outcomes (VA, lesion activity status) and ocular adverse events were recorded in a prospectively designed electronic database. Index visit characteristics associated with the 12-month VA outcome were identified using mixed effects linear regression. Results: Mean change in VA in the cohort after 12 months was +4.7 logMAR letters (95%CI: 3.4 to 6.1) with a mean of 7.0 injections. No significant difference was found in change in VA or number of injections by type or size of the lesion. Median time to inactivation of lesions was 194 days. VA at the index visit was the strongest predictor for the 12-month outcomes. Infectious endophthalmitis occurred in 2 cases, retinal detachment in 1 case from a total of 9,162 injections. Conclusions: These findings indicate that VEGF inhibitors can achieve reasonably good outcomes for wet AMD when used in routine clinical practice.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Ophthalmology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2 July 2013
Deposited On:23 Aug 2013 14:35
Last Modified:05 Apr 2016 16:56
Publisher:Association for Research in Vision and Ophthalmology
ISSN:0146-0404
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1167/iovs.13-11993
PubMed ID:23821201

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