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Roux-en-Y gastric bypass surgery in rats alters gut microbiota profile along the intestine


Osto, Melania; Abegg, Kathrin; Bueter, Marco; le Roux, Carel W; Cani, Patrice D; Lutz, Thomas A (2013). Roux-en-Y gastric bypass surgery in rats alters gut microbiota profile along the intestine. Physiology and Behavior, 119:92-96.

Abstract

Roux-en-Y gastric bypass (RYGB) surgery might modify the gut microbiota composition differently in the three distinct anatomical sections of the small intestine compared to sham surgery. We showed that RYGB induced changes in the microbiota of the alimentary limb and the common channel resembling those seen after prebiotic treatment or weight loss by dieting. These changes may be associated with altered production of intestinal hormones known to control energy balance. Postsurgical modulation of gut microbiota may significantly contribute to the beneficial metabolic effects of RYGB surgery.

Abstract

Roux-en-Y gastric bypass (RYGB) surgery might modify the gut microbiota composition differently in the three distinct anatomical sections of the small intestine compared to sham surgery. We showed that RYGB induced changes in the microbiota of the alimentary limb and the common channel resembling those seen after prebiotic treatment or weight loss by dieting. These changes may be associated with altered production of intestinal hormones known to control energy balance. Postsurgical modulation of gut microbiota may significantly contribute to the beneficial metabolic effects of RYGB surgery.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
05 Vetsuisse Faculty > Institute of Veterinary Physiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2013
Deposited On:12 Sep 2013 14:48
Last Modified:07 Dec 2017 22:16
Publisher:Elsevier
ISSN:0031-9384
Publisher DOI:https://doi.org/10.1016/j.physbeh.2013.06.008
PubMed ID:23770330

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