Header

UZH-Logo

Maintenance Infos

Sonic hedgehog and Wnt: antagonists in morphogenesis but collaborators in axon guidance


Avilés, Evelyn C; Wilson, Nicole H; Stoeckli, Esther T (2013). Sonic hedgehog and Wnt: antagonists in morphogenesis but collaborators in axon guidance. Frontiers in Cellular Neuroscience:7:86.

Abstract

As indicated by their name, morphogens were first identified for their role in the formation of tissues early in development. Secreted from a source, they spread through the tissue to form gradients by which they affect the differentiation of precursor cells in a concentration-dependent manner. In this context, the antagonistic roles of the morphogens of the Wnt family and Sonic hedgehog (Shh) in the specification of cell types along the dorso-ventral axis of the neural tube have been studied in detail. However, more recently, morphogens have been demonstrated to act well beyond the early stages of nervous system development, as additional roles of morphogen gradients in vertebrate neural circuit formation have been identified. Both Wnt and Shh affect neural circuit formation at several stages by their influence on neurite extension, axon pathfinding and synapse formation. In this review, we will summarize the mechanisms of morphogen function during axon guidance in the vertebrate nervous system.

Abstract

As indicated by their name, morphogens were first identified for their role in the formation of tissues early in development. Secreted from a source, they spread through the tissue to form gradients by which they affect the differentiation of precursor cells in a concentration-dependent manner. In this context, the antagonistic roles of the morphogens of the Wnt family and Sonic hedgehog (Shh) in the specification of cell types along the dorso-ventral axis of the neural tube have been studied in detail. However, more recently, morphogens have been demonstrated to act well beyond the early stages of nervous system development, as additional roles of morphogen gradients in vertebrate neural circuit formation have been identified. Both Wnt and Shh affect neural circuit formation at several stages by their influence on neurite extension, axon pathfinding and synapse formation. In this review, we will summarize the mechanisms of morphogen function during axon guidance in the vertebrate nervous system.

Statistics

Citations

17 citations in Web of Science®
19 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

73 downloads since deposited on 16 Sep 2013
23 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:10 June 2013
Deposited On:16 Sep 2013 06:35
Last Modified:07 Dec 2017 22:21
Publisher:Frontiers Research Foundation
ISSN:1662-5102
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3389/fncel.2013.00086
PubMed ID:23772206

Download

Download PDF  'Sonic hedgehog and Wnt: antagonists in morphogenesis but collaborators in axon guidance'.
Preview
Content: Published Version
Filetype: PDF
Size: 2MB
View at publisher
Licence: Creative Commons: Attribution 3.0 Unported (CC BY 3.0)