Header

UZH-Logo

Maintenance Infos

Competition-colonization trade-off promotes coexistence of low-virulence viral strains


Ojosnegros, S; Delgado-Eckert, E; Beerenwinkel, N (2012). Competition-colonization trade-off promotes coexistence of low-virulence viral strains. Journal of the Royal Society Interface, 9(74):2244-2254.

Abstract

RNA viruses exist as genetically diverse populations displaying a range of virulence degrees. The evolution of virulence in viral populations is, however, poorly understood. On the basis of the experimental observation of an RNA virus clone in cell culture diversifying into two subpopulations of different virulence, we study the dynamics of mutating virus populations with varying virulence. We introduce a competition-colonization trade-off into standard mathematical models of intra-host viral infection. Colonizers are fast-spreading virulent strains, whereas the competitors are less-virulent variants but more successful within co-infected cells. We observe a two-step dynamics of the population. Early in the infection, the population is dominated by colonizers, which later are outcompeted by competitors. Our simulations suggest the existence of steady state in which all virulence classes coexist but are dominated by the most competitive ones. This equilibrium implies collective virulence attenuation in the population, in contrast to previous models predicting evolution of the population towards increased virulence.

Abstract

RNA viruses exist as genetically diverse populations displaying a range of virulence degrees. The evolution of virulence in viral populations is, however, poorly understood. On the basis of the experimental observation of an RNA virus clone in cell culture diversifying into two subpopulations of different virulence, we study the dynamics of mutating virus populations with varying virulence. We introduce a competition-colonization trade-off into standard mathematical models of intra-host viral infection. Colonizers are fast-spreading virulent strains, whereas the competitors are less-virulent variants but more successful within co-infected cells. We observe a two-step dynamics of the population. Early in the infection, the population is dominated by colonizers, which later are outcompeted by competitors. Our simulations suggest the existence of steady state in which all virulence classes coexist but are dominated by the most competitive ones. This equilibrium implies collective virulence attenuation in the population, in contrast to previous models predicting evolution of the population towards increased virulence.

Statistics

Citations

5 citations in Web of Science®
5 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

69 downloads since deposited on 18 Sep 2013
16 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:Special Collections > SystemsX.ch
Special Collections > SystemsX.ch > Research, Technology and Development Projects > InfectX
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2012
Deposited On:18 Sep 2013 12:44
Last Modified:21 Nov 2017 16:50
Publisher:Royal Society Publishing
ISSN:1742-5662
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1098/rsif.2012.0160
PubMed ID:22513722

Download

Download PDF  'Competition-colonization trade-off promotes coexistence of low-virulence viral strains'.
Preview
Filetype: PDF
Size: 798kB
View at publisher