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A template for new drugs against Alzheimer's Disease


Aguzzi, Adriano; Gitler, Aaron D (2013). A template for new drugs against Alzheimer's Disease. Cell, 154(6):1182-1184.

Abstract

Alzheimer's disease (AD) is associated with the deposition of β-amyloid (Aβ) plaques in the brain. In this issue, by cleverly processing patient samples, Lu et al. define a novel structural model of Aβ fibrils from AD brain, revealing surprising differences from in vitro fibrils. These findings may lead to structure-specific inhibitors and more selective amyloid-imaging methods.

Abstract

Alzheimer's disease (AD) is associated with the deposition of β-amyloid (Aβ) plaques in the brain. In this issue, by cleverly processing patient samples, Lu et al. define a novel structural model of Aβ fibrils from AD brain, revealing surprising differences from in vitro fibrils. These findings may lead to structure-specific inhibitors and more selective amyloid-imaging methods.

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13 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2013
Deposited On:23 Sep 2013 09:11
Last Modified:07 Dec 2017 22:36
Publisher:Cell Press (Elsevier)
ISSN:0092-8674
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.cell.2013.08.049
PubMed ID:24034239

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