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Luminal matrices: An inside view on organ morphogenesis


Luschnig, Stefan; Uv, Anne (2014). Luminal matrices: An inside view on organ morphogenesis. Experimental Cell Research, 321(1):64-70.

Abstract

Tubular epithelia come in various shapes and sizes to accommodate the specific needs for transport, excretion and absorption in multicellular organisms. The intestinal tract, glandular organs and conduits for liquids and gases are all lined by a continuous layer of epithelial cells, which form the boundary of the luminal space. Defects in epithelial architecture and lumen dimensions will impair transport and can lead to serious organ malfunctions. Not surprisingly, multiple cellular and molecular mechanisms participate in controlling size and form of tubular epithelial structures. One intriguing aspect of epithelial organ formation is the coordinate behavior of individual cells as they mold the mature lumen. Here, we focus on recent findings, primarily from Drosophila, demonstrating that informative cues can emanate from the developing organ lumen in the form of solid luminal material. The luminal material is produced by the surrounding epithelium and helps to coordinate changes in shape and arrangement of the very same cells, resulting in correct lumen dimensions.

Abstract

Tubular epithelia come in various shapes and sizes to accommodate the specific needs for transport, excretion and absorption in multicellular organisms. The intestinal tract, glandular organs and conduits for liquids and gases are all lined by a continuous layer of epithelial cells, which form the boundary of the luminal space. Defects in epithelial architecture and lumen dimensions will impair transport and can lead to serious organ malfunctions. Not surprisingly, multiple cellular and molecular mechanisms participate in controlling size and form of tubular epithelial structures. One intriguing aspect of epithelial organ formation is the coordinate behavior of individual cells as they mold the mature lumen. Here, we focus on recent findings, primarily from Drosophila, demonstrating that informative cues can emanate from the developing organ lumen in the form of solid luminal material. The luminal material is produced by the surrounding epithelium and helps to coordinate changes in shape and arrangement of the very same cells, resulting in correct lumen dimensions.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:Apical extracellular matrix; Organogenesis; Tubulogenesis; Lumen; Chitin; Mechanical forces; Luminal pressure
Language:English
Date:2014
Deposited On:11 Oct 2013 16:00
Last Modified:05 Apr 2016 17:01
Publisher:Elsevier
ISSN:0014-4827
Publisher DOI:https://doi.org/10.1016/j.yexcr.2013.09.010
PubMed ID:24075963

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