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Efavirenz intoxication due to a new CYP2B6 constellation


Anagnostopoulos, Alexia; Rotger, Margalida; Aouri, Manel; Kuster, Stefan P; Telenti, Amalio; Décosterd, Laurent A; Günthard, Huldrych F (2013). Efavirenz intoxication due to a new CYP2B6 constellation. Antiviral Therapy, 18(5):735-738.

Abstract

Here, we describe severe neuropsychiatric symptoms in an HIV-positive Asian man with extremely high efavirenz plasma levels while receiving standard treatment with efavirenz/tenofovir/emtricitabine fixed-dose regimen. Genetic examination revealed compound homozygosity for loss-of-function alleles of CYP2B6, including coding for a rare truncated protein. Neuropsychiatric symptoms resolved completely after efavirenz discontinuation.

Abstract

Here, we describe severe neuropsychiatric symptoms in an HIV-positive Asian man with extremely high efavirenz plasma levels while receiving standard treatment with efavirenz/tenofovir/emtricitabine fixed-dose regimen. Genetic examination revealed compound homozygosity for loss-of-function alleles of CYP2B6, including coding for a rare truncated protein. Neuropsychiatric symptoms resolved completely after efavirenz discontinuation.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:10 Oct 2013 13:48
Last Modified:05 Apr 2016 17:02
Publisher:International Medical Press
ISSN:1359-6535
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.3851/IMP2571
PubMed ID:23640958

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