Header

UZH-Logo

Maintenance Infos

Novel water-soluble Tc-99m(I)/Re(I)-porphyrin conjugates as potential multimodal agents for molecular imaging


Spagnul, Cinzia; Alberto, Roger; Gasser, Gilles; Ferrari, Stefano; Pierroz, Vanessa; Bergamo, Alberta; Gianferrara, Teresa; Alessio, Enzo (2013). Novel water-soluble Tc-99m(I)/Re(I)-porphyrin conjugates as potential multimodal agents for molecular imaging. Journal of Inorganic Biochemistry, 122:57-65.

Abstract

The synthesis and characterization of two novel water soluble porphyrins with three meso pyridyl rings and one peripheral chelator - either a diethylenetriamine unit (4) or a bipyridyl fragment (8) - for binding to the {(99m)Tc(CO)3}(+) moiety is reported. In 8, despite the presence of a flexible and hydrophilic PEG-like linker that connects the bpy unit to the macrocycle, good water solubility was only obtained by methylation of the pyridyl N atoms that provided three extra positive charges. Furthermore, the water-soluble conjugates of 4 and 8 with either one fac-{Re(CO)3}(+) (9 and 10, respectively) or one fac-{(99m)Tc(CO)3}(+) fragment (9a and 10a, respectively) are described.

Abstract

The synthesis and characterization of two novel water soluble porphyrins with three meso pyridyl rings and one peripheral chelator - either a diethylenetriamine unit (4) or a bipyridyl fragment (8) - for binding to the {(99m)Tc(CO)3}(+) moiety is reported. In 8, despite the presence of a flexible and hydrophilic PEG-like linker that connects the bpy unit to the macrocycle, good water solubility was only obtained by methylation of the pyridyl N atoms that provided three extra positive charges. Furthermore, the water-soluble conjugates of 4 and 8 with either one fac-{Re(CO)3}(+) (9 and 10, respectively) or one fac-{(99m)Tc(CO)3}(+) fragment (9a and 10a, respectively) are described.

Statistics

Citations

23 citations in Web of Science®
22 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Molecular Cancer Research
07 Faculty of Science > Institute of Molecular Cancer Research

07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:570 Life sciences; biology
540 Chemistry
Language:English
Date:2013
Deposited On:18 Oct 2013 11:06
Last Modified:05 Apr 2016 17:02
Publisher:Elsevier
ISSN:0162-0134
Publisher DOI:https://doi.org/10.1016/j.jinorgbio.2012.12.016
PubMed ID:23474539

Download

Full text not available from this repository.
View at publisher