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Emergence of a C-terminal seve 1 n amino acid elongation of NS1 around 1950 2 conferred a minor growth advantage to former seasonal influenza A viruses


Lohrmann, F; Dijkman, R; Stertz, S; Thiel, V; Haller, O; Staeheli, P; Kochs, G (2013). Emergence of a C-terminal seve 1 n amino acid elongation of NS1 around 1950 2 conferred a minor growth advantage to former seasonal influenza A viruses. Journal of Virology, 87(20):11300-11303.

Abstract

Influenza A viruses circulating in humans from ∼1950 to ∼1987 featured a nonstructural (NS1) protein with a C-terminal extension of seven amino acids. The biological significance of this NS1 elongation remained elusive. We observed that replication kinetics of the wild-type virus A/Hong Kong/01/68 (H3N2) and a mutant encoding a truncated NS1 were indistinguishable in most experimental systems. However, wild-type virus outcompeted the mutant during mixed infections, suggesting that the NS1 extension conferred minor growth advantages.

Abstract

Influenza A viruses circulating in humans from ∼1950 to ∼1987 featured a nonstructural (NS1) protein with a C-terminal extension of seven amino acids. The biological significance of this NS1 elongation remained elusive. We observed that replication kinetics of the wild-type virus A/Hong Kong/01/68 (H3N2) and a mutant encoding a truncated NS1 were indistinguishable in most experimental systems. However, wild-type virus outcompeted the mutant during mixed infections, suggesting that the NS1 extension conferred minor growth advantages.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Virology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:7 August 2013
Deposited On:28 Oct 2013 07:05
Last Modified:05 Apr 2016 17:04
Publisher:American Society for Microbiology
ISSN:0022-538X
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1128/JVI.01271-13
Official URL:http://jvi.asm.org/
PubMed ID:23926347

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