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Multigene assays for classification, prognosis, and prediction in breast cancer: a critical review on the background and clinical utility


Sinn, P; Aulmann, S; Wirtz, R; Schott, S; Marmé, F; Varga, Z; Lebeau, A; Kreipe, H; Schneeweiss, A (2013). Multigene assays for classification, prognosis, and prediction in breast cancer: a critical review on the background and clinical utility. Geburtshilfe und Frauenheilkunde, 73(9):932-940.

Abstract

Gene signatures which are based on multigene profiling assays have been developed for the purpose to better define the prognosis and prediction of therapy results in early-stage breast cancer. These assays were designed to be more specific than conventional clinico-pathologic parameters in the selection of patients for (neo-)adjuvant treatment and in effect help to avoid unnecessary cytotoxic treatment. In this review we describe molecular risk scores, for which tests are commercially available (PAM50®, MammaTyper®, MammaPrint®, Oncotype DX®, Endopredict®, Genomic Grade Index®) and IHC risk scores (Mammostrat ® and IHC4), and discuss the current evidence of their clinical use.

Abstract

Gene signatures which are based on multigene profiling assays have been developed for the purpose to better define the prognosis and prediction of therapy results in early-stage breast cancer. These assays were designed to be more specific than conventional clinico-pathologic parameters in the selection of patients for (neo-)adjuvant treatment and in effect help to avoid unnecessary cytotoxic treatment. In this review we describe molecular risk scores, for which tests are commercially available (PAM50®, MammaTyper®, MammaPrint®, Oncotype DX®, Endopredict®, Genomic Grade Index®) and IHC risk scores (Mammostrat ® and IHC4), and discuss the current evidence of their clinical use.

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24 citations in Web of Science®
28 citations in Scopus®
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Additional indexing

Other titles:Multigenassays zur Beurteilung der Klassifikation, Prognose und Prädiktion beim Mammakarzinom. Ein kritischer Review zum Hintergrund und klinischen Nutzen
Item Type:Journal Article, not refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:28 Oct 2013 16:27
Last Modified:07 Dec 2017 23:09
Publisher:Thieme Publishing
ISSN:0016-5751
Publisher DOI:https://doi.org/10.1055/s-0033-1350831

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