Header

UZH-Logo

Maintenance Infos

Attenuation correction maps for SPECT myocardial perfusion imaging from contrast-enhanced coronary CT angiography: Gemstone spectral imaging with single-source dual energy and material decomposition


Fuchs, Tobias A; Sah, Bert-Ram; Stehli, Julia; Bull, Sacha; Dougoud, Svetlana; Huellner, Martin W; Gaemperli, Oliver; Kaufmann, Philipp A (2013). Attenuation correction maps for SPECT myocardial perfusion imaging from contrast-enhanced coronary CT angiography: Gemstone spectral imaging with single-source dual energy and material decomposition. Journal of Nuclear Medicine, 54(12):2077-2080.

Abstract

The aim of this study was to explore the feasibility of attenuation correction (AC) of myocardial perfusion imaging (MPI) with a virtual unenhanced cardiac CT scan synthesized from contrast-enhanced single-source dual-energy coronary CT angiography.
METHODS: Segmental myocardial percentage uptake values obtained with AC were analyzed by use of correlation analysis and Bland-Altman limits of agreement (20-segment model), and clinical agreement was evaluated in 30 patients.
RESULTS: The 2 methods showed an excellent correlation for segmental myocardial percentage uptake at stress (r = 0.93; P < 0.001; low dose) and at rest (r = 0.90; P < 0.001; high dose) with narrow Bland-Altman limits of agreement (-6.8% to 7.8% and -7.8% to 7.4%, respectively). The levels of clinical agreement of SPECT MPI corrected with standard versus virtual unenhanced CT AC were 99% per coronary territory and 97% per patient.
CONCLUSION: Our results suggest that AC of SPECT MPI with a virtual unenhanced CT scan synthesized from contrast-enhanced coronary CT angiography is feasible and reliable.

Abstract

The aim of this study was to explore the feasibility of attenuation correction (AC) of myocardial perfusion imaging (MPI) with a virtual unenhanced cardiac CT scan synthesized from contrast-enhanced single-source dual-energy coronary CT angiography.
METHODS: Segmental myocardial percentage uptake values obtained with AC were analyzed by use of correlation analysis and Bland-Altman limits of agreement (20-segment model), and clinical agreement was evaluated in 30 patients.
RESULTS: The 2 methods showed an excellent correlation for segmental myocardial percentage uptake at stress (r = 0.93; P < 0.001; low dose) and at rest (r = 0.90; P < 0.001; high dose) with narrow Bland-Altman limits of agreement (-6.8% to 7.8% and -7.8% to 7.4%, respectively). The levels of clinical agreement of SPECT MPI corrected with standard versus virtual unenhanced CT AC were 99% per coronary territory and 97% per patient.
CONCLUSION: Our results suggest that AC of SPECT MPI with a virtual unenhanced CT scan synthesized from contrast-enhanced coronary CT angiography is feasible and reliable.

Statistics

Citations

2 citations in Web of Science®
2 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:25 Oct 2013 07:07
Last Modified:05 Apr 2016 17:04
Publisher:Society of Nuclear Medicine
ISSN:0161-5505
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.2967/jnumed.113.123570
PubMed ID:24144564

Download

Full text not available from this repository.
View at publisher