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Equine Keratomycosis in Switzerland: a retrospective evaluation of 35 horses (January 2000 – August 2011)


Voelter-Ratson, K; Pot, S A; Florin, M; Spiess, B M (2013). Equine Keratomycosis in Switzerland: a retrospective evaluation of 35 horses (January 2000 – August 2011). Equine Veterinary Journal, 45(5):608-612.

Abstract

Reason for performing study: Keratomycosis is a severe disease in horses. Geographical differences in fungi causing keratomycosis and susceptibility of the organisms to antifungal drugs exist. Only few publications concerning this disease originating from Europe. Objective: To retrospectively compare the clinical data of 36 eyes with keratomycosis, diagnosed in 35 horses between January 2000 and August 2011 at the Vetsuisse Faculty of Switzerland. Signalment, season, prior treatment, clinical appearance, surgical and medical treatment, treatment duration and globe survival were evaluated. Methods: Medical records were screened for keratomycosis in horses with a definitive cytological or histological diagnosis. Results: Thirty-one of 36 eyes (86.1%) presented with ulcerative keratitis, 2/36 (5.55%) showed diffuse corneal infiltration, 2/36 (5.55%) had a superficial punctate keratitis and 1/36 (2.8%) a fluorescein-negative fungal plaque. Two out of 6 fungal cultures were positive for Aspergillus spp. Thirty eyes received medical and surgical treatment, while 3 eyes were treated medically only. In 3 patients the globe was removed at the time of first presentation. Gender, age, prior treatment with antibiotics or steroids, or type of surgical approach did not significantly influence the outcome. Twenty-three of 36 eyes (63.9%) were saved and at least partially visual, 11/36 eyes (30.5%) were enucleated and 2 horses (2/36 eyes (5.6%)) were euthanized. Medical treatment protocols were compared in the 31 eyes presenting with ulcerative keratitis. In this group, 3/31 globes were immediately enucleated, 16/31 eyes were treated topically with voriconazole or voriconazole/fluconazole and 12/31 with other antifungal drug combinations. Different medication protocols did not significantly affect the outcome. Conclusions: Regarding outcome, no significant differences between different medical treatment protocols or types of surgical approach could be seen. Future studies in central Europe should focus on the identification of fungal pathogens, susceptibility patterns and the efficacy of antifungal drug therapies.

Abstract

Reason for performing study: Keratomycosis is a severe disease in horses. Geographical differences in fungi causing keratomycosis and susceptibility of the organisms to antifungal drugs exist. Only few publications concerning this disease originating from Europe. Objective: To retrospectively compare the clinical data of 36 eyes with keratomycosis, diagnosed in 35 horses between January 2000 and August 2011 at the Vetsuisse Faculty of Switzerland. Signalment, season, prior treatment, clinical appearance, surgical and medical treatment, treatment duration and globe survival were evaluated. Methods: Medical records were screened for keratomycosis in horses with a definitive cytological or histological diagnosis. Results: Thirty-one of 36 eyes (86.1%) presented with ulcerative keratitis, 2/36 (5.55%) showed diffuse corneal infiltration, 2/36 (5.55%) had a superficial punctate keratitis and 1/36 (2.8%) a fluorescein-negative fungal plaque. Two out of 6 fungal cultures were positive for Aspergillus spp. Thirty eyes received medical and surgical treatment, while 3 eyes were treated medically only. In 3 patients the globe was removed at the time of first presentation. Gender, age, prior treatment with antibiotics or steroids, or type of surgical approach did not significantly influence the outcome. Twenty-three of 36 eyes (63.9%) were saved and at least partially visual, 11/36 eyes (30.5%) were enucleated and 2 horses (2/36 eyes (5.6%)) were euthanized. Medical treatment protocols were compared in the 31 eyes presenting with ulcerative keratitis. In this group, 3/31 globes were immediately enucleated, 16/31 eyes were treated topically with voriconazole or voriconazole/fluconazole and 12/31 with other antifungal drug combinations. Different medication protocols did not significantly affect the outcome. Conclusions: Regarding outcome, no significant differences between different medical treatment protocols or types of surgical approach could be seen. Future studies in central Europe should focus on the identification of fungal pathogens, susceptibility patterns and the efficacy of antifungal drug therapies.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Equine Department
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Language:English
Date:2 August 2013
Deposited On:05 Nov 2013 13:19
Last Modified:05 Apr 2016 17:05
Publisher:Wiley-Blackwell
ISSN:0425-1644
Publisher DOI:https://doi.org/10.1111/evj.12042

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