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First meeting of the European canine lymphoma group. Workshop: state of the art and comparative aspects in canine lymphoma. CH-Lugano, 22 June 2013


Comazzi, St; Guscetti, F; Marconato, L (2014). First meeting of the European canine lymphoma group. Workshop: state of the art and comparative aspects in canine lymphoma. CH-Lugano, 22 June 2013. Hematological oncology, 32(2):68-71.

Abstract

This satellite meeting to the 12th International Conference on Malignant Lymphoma was conceived to bring together European researchers focused on canine lymphoma to explore several facets of this promising model of human disease. A series of invited lectures showed striking similarities between the two diseases namely in topics related to pathogenesis, diagnosis and classification, and therapy. In particular, the potential value of the model was shown at the level of the NF-KB/p65 pathway, the Bcl-2 family of proteins, Ki67 and the S-phase fraction, as well as the MMPs, VEGF, and PDGF. The utility of the growing body of well-characterized canine cell lines was stressed. The value of cytology and flow cytometry as tools for diagnosis, disease progression monitoring and prognosis were emphasized, while the failure so far of the standard immunohistochemical panel to differentiate between germinal center and non-germinal center DLBCL subtypes in dogs was discussed. Further contributions included the report of encouraging results from an immunotherapy trial, an overview on the use of radiation therapy for canine lymphoma, and the role of surgery in splenic lymphoma. Altogether the success of this meeting, attended by more than 160 participants, documents the rising interest for the spontaneous canine lymphoma model.

Abstract

This satellite meeting to the 12th International Conference on Malignant Lymphoma was conceived to bring together European researchers focused on canine lymphoma to explore several facets of this promising model of human disease. A series of invited lectures showed striking similarities between the two diseases namely in topics related to pathogenesis, diagnosis and classification, and therapy. In particular, the potential value of the model was shown at the level of the NF-KB/p65 pathway, the Bcl-2 family of proteins, Ki67 and the S-phase fraction, as well as the MMPs, VEGF, and PDGF. The utility of the growing body of well-characterized canine cell lines was stressed. The value of cytology and flow cytometry as tools for diagnosis, disease progression monitoring and prognosis were emphasized, while the failure so far of the standard immunohistochemical panel to differentiate between germinal center and non-germinal center DLBCL subtypes in dogs was discussed. Further contributions included the report of encouraging results from an immunotherapy trial, an overview on the use of radiation therapy for canine lymphoma, and the role of surgery in splenic lymphoma. Altogether the success of this meeting, attended by more than 160 participants, documents the rising interest for the spontaneous canine lymphoma model.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2014
Deposited On:14 Nov 2013 10:39
Last Modified:05 Apr 2016 17:08
Publisher:Wiley-Blackwell
ISSN:0278-0232
Publisher DOI:https://doi.org/10.1002/hon.2115

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