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Human hemato-lymphoid system mice: current use and future potential for medicine


Rongvaux, A; Takizawa, H; Strowig, T; Willinger, T; Eynon, E E; Flavell, R A; Manz, M G (2013). Human hemato-lymphoid system mice: current use and future potential for medicine. Annual Review of Immunology, 31:635-674.

Abstract

To directly study complex human hemato-lymphoid system physiology and respective system-associated diseases in vivo, human-to-mouse xenotransplantation models for human blood and blood-forming cells and organs have been developed over the past three decades. We here review the fundamental requirements and the remarkable progress made over the past few years in improving these systems, the current major achievements reached by use of these models, and the future challenges to more closely model and study human health and disease and to achieve predictive preclinical testing of both prevention measures and potential new therapies.

Abstract

To directly study complex human hemato-lymphoid system physiology and respective system-associated diseases in vivo, human-to-mouse xenotransplantation models for human blood and blood-forming cells and organs have been developed over the past three decades. We here review the fundamental requirements and the remarkable progress made over the past few years in improving these systems, the current major achievements reached by use of these models, and the future challenges to more closely model and study human health and disease and to achieve predictive preclinical testing of both prevention measures and potential new therapies.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:18 Nov 2013 09:30
Last Modified:05 Apr 2016 17:09
Publisher:Annual Reviews
ISSN:0732-0582
Publisher DOI:https://doi.org/10.1146/annurev-immunol-032712-095921
PubMed ID:23330956

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