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Tissue microarrays and biomarker validation in molecular diagnostics


Storz, Martina; Moch, Holger (2013). Tissue microarrays and biomarker validation in molecular diagnostics. In: Cheng, Liang; Zhang, David Y; Eble, John N. Molecular Genetic Pathology. New York: Springer, 455-461.

Abstract

The technology of tissue microarrays (TMAs) was developed against the background of decoding the human genome and the widespread application of high-density cDNA microarrays. TMAs facilitate comprehensive molecular profiling of cancer specimens with minimal tissue requirements. A TMA is a paraffin block composed of multiple tissue specimens. TMA sections provide targets for parallel in situ detection of DNA, RNA, and protein targets, allowing the rapid analysis of hundreds of molecular markers in the same set of specimens. Multiple specimens can be simultaneously investigated with different in situ techniques under identical laboratory conditions.

Abstract

The technology of tissue microarrays (TMAs) was developed against the background of decoding the human genome and the widespread application of high-density cDNA microarrays. TMAs facilitate comprehensive molecular profiling of cancer specimens with minimal tissue requirements. A TMA is a paraffin block composed of multiple tissue specimens. TMA sections provide targets for parallel in situ detection of DNA, RNA, and protein targets, allowing the rapid analysis of hundreds of molecular markers in the same set of specimens. Multiple specimens can be simultaneously investigated with different in situ techniques under identical laboratory conditions.

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Additional indexing

Item Type:Book Section, not refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:21 Nov 2013 08:55
Last Modified:05 Apr 2016 17:10
Publisher:Springer
ISBN:978-1-4614-4800-6
Additional Information:2nd Edition
Publisher DOI:https://doi.org/10.1007/978-1-4614-4800-6_15
Related URLs:http://www.springer.com/medicine/pathology/book/978-1-4614-4799-3
http://www.recherche-portal.ch/zbz/action/display.do?fn=display&vid=ZAD&doc=ebi01_prod009926327 (Library Catalogue)

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