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Interleukin-1 receptor antagonist-treatment of patients with type 2 diabetes


Larsen, Claus Morten; Faulenbach, Mirjam; Vaag, Allan; Vølund, Aage; Ehses, Jan; Seifert, Burkhardt; Mandrup-Poulsen, Thomas; Donath, Marc (2007). Interleukin-1 receptor antagonist-treatment of patients with type 2 diabetes. Ugeskrift for laeger, 169(45):3868-3871.

Abstract

Interleukin-1 receptor antagonist (IL-1Ra) expression is reduced in islets of patients with type 2 diabetes. 70 patients with type 2 diabetes were randomized to treatment with anakinra (IL-1Ra) or placebo for 13 weeks. Following treatment glycated hemoglobin was 0.46 percent lower, C-peptide secretion was enhanced, and systemic IL-6 and C-reactive protein levels were reduced in the anakinra group compared to the placebo group. Insulin resistance remained unchanged. Blocking IL-1 activity improved glycemia and b-cell secretory function and reduced markers of systemic inflammation.

Abstract

Interleukin-1 receptor antagonist (IL-1Ra) expression is reduced in islets of patients with type 2 diabetes. 70 patients with type 2 diabetes were randomized to treatment with anakinra (IL-1Ra) or placebo for 13 weeks. Following treatment glycated hemoglobin was 0.46 percent lower, C-peptide secretion was enhanced, and systemic IL-6 and C-reactive protein levels were reduced in the anakinra group compared to the placebo group. Insulin resistance remained unchanged. Blocking IL-1 activity improved glycemia and b-cell secretory function and reduced markers of systemic inflammation.

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Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:Danish
Date:2007
Deposited On:03 Dec 2013 16:34
Last Modified:05 Apr 2016 17:12
Publisher:Almindelige Danske Laegeforening
ISSN:0041-5782
PubMed ID:18031661

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