Concern and interest are rising that climate change may have an adverse impact on slope stability in mountain regions. Rock slopes in high mountain areas with glaciers and permafrost are particularly sensitive to atmospheric warming. In fact, several large rock slope failures have been observed in high mountain areas around the world in recent years. However, the detection of changes in the frequency or magnitude of such slope failures is fraught with a number of difficulties and has only recently been addressed. Here we outline several approaches that could be used to detect a change in high mountain slope failure activity. Rather than present research results, we provide a conceptual design of how research in this field could be strengthened.