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Targeting TKI-resistance in NSCLC: importance of rebiopsy and molecular diagnostics — A case study


Stoehlmacher-Williams, Jan; Ehninger, Gerhard; Zimmermann, Dieter R; Merkelbach-Bruse, Sabine; Schildhaus, Hans-Ulrich; Buettner, Reinhard (2013). Targeting TKI-resistance in NSCLC: importance of rebiopsy and molecular diagnostics — A case study. Cancer Treatment Communications, 1(1):1-5.

Abstract

We present the case of a 27 year old woman with widely disseminated metastatic adenocarcinoma of the lung who outlived stage IV diagnosis of NSCLC by more than 4 years. Based on rebiopsy and molecular diagnostics of oncogene dependency, appropriately targeted therapies were successfully employed up to a fifth line oral monotherapy with the ErbB family blocker afatinib for a final 11 months. We stress the importance of rebiopsies, the corresponding selection of targeted therapies, and the observed gain in quality of live even in end stage disease.

Abstract

We present the case of a 27 year old woman with widely disseminated metastatic adenocarcinoma of the lung who outlived stage IV diagnosis of NSCLC by more than 4 years. Based on rebiopsy and molecular diagnostics of oncogene dependency, appropriately targeted therapies were successfully employed up to a fifth line oral monotherapy with the ErbB family blocker afatinib for a final 11 months. We stress the importance of rebiopsies, the corresponding selection of targeted therapies, and the observed gain in quality of live even in end stage disease.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:NSCLC, Secondary resistance, Afatinib, EGFR-TKI, Rebiopsy, Fifth line
Language:English
Date:2013
Deposited On:12 Dec 2013 09:57
Last Modified:28 Sep 2017 15:28
Publisher:Elsevier
ISSN:2213-0896
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.ctrc.2013.07.001

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