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Entwicklung von Übergewicht und Adipositas beim Mammakarzinom und ihre Bedeutung für Diagnose und klinisches Management: Resultate der Basler Mammakarzinom-Datenbank 1990-2009


Güth, Uwe; Schmid, Seraina; Eichholzer, Monika (2013). Entwicklung von Übergewicht und Adipositas beim Mammakarzinom und ihre Bedeutung für Diagnose und klinisches Management: Resultate der Basler Mammakarzinom-Datenbank 1990-2009. Praxis, 102(8):473-480.

Abstract

Greater body fatness was found to be a risk factor for postmenopausal breast cancer (BC); furthermore this factor appears to be associated with poor prognosis. These findings were tested by analyzing 1459 patients whose cases were recorded in the Basler Mammakarzinom-Datenbank (1990-2009) and the Swiss Health Surveys (1992-2007). Considering only postmenopausal women, no association between a rising body mass index (BMI) and BC development was observed. BMI was found to be a significant factor for tumor size (this applied to self-detected tumors and for lesions detected by radiological examinations) and had a positive correlation to advanced disease stage, unfavorable grading and a higher St. Galler risk score. In most therapy modes, patients with increasing BMI demonstrated a higher compliance and persistence to adjuvant therapies.

Abstract

Greater body fatness was found to be a risk factor for postmenopausal breast cancer (BC); furthermore this factor appears to be associated with poor prognosis. These findings were tested by analyzing 1459 patients whose cases were recorded in the Basler Mammakarzinom-Datenbank (1990-2009) and the Swiss Health Surveys (1992-2007). Considering only postmenopausal women, no association between a rising body mass index (BMI) and BC development was observed. BMI was found to be a significant factor for tumor size (this applied to self-detected tumors and for lesions detected by radiological examinations) and had a positive correlation to advanced disease stage, unfavorable grading and a higher St. Galler risk score. In most therapy modes, patients with increasing BMI demonstrated a higher compliance and persistence to adjuvant therapies.

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Additional indexing

Other titles:Development of overweight and obesity in breast cancer patients and its significance for diagnosis and clinical management: results of the Basel Breast Cancer Database 1990-2009
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:2013
Deposited On:13 Dec 2013 14:31
Last Modified:05 Apr 2016 17:15
Publisher:Hans Huber
ISSN:1661-8157
Publisher DOI:https://doi.org/10.1024/1661-8157/a001255
PubMed ID:23570924

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