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Subacute cutaneous lupus erythematosus triggered by radiotherapy


Kolm, Isabel; Pawlik, E; Eggmann, N; Kamarachev, J; Kerl, K; French, L E; Hofbauer, G F L (2013). Subacute cutaneous lupus erythematosus triggered by radiotherapy. Case Reports in Dermatology, 5(2):232-235.

Abstract

BACKGROUND: The origin of collagen autoimmune diseases is not fully understood. Some studies postulate a mechanism of molecular mimicry or heterologous immunity following viral infections triggering autoimmunity. Apart from infections, other exogenous factors such as visible light or X-rays have been reported to incite autoimmunity.
CASE REPORT: We report a case of histologically and serologically confirmed subacute lupus erythematosus (SCLE) following radiotherapy for breast cancer.
DISCUSSION: The close temporal and spatial correlation between radiotherapy and onset of SCLE in this patient suggests that an autoimmune reaction may have been triggered locally by functionally altering the immune system and breaking self-tolerance.

Abstract

BACKGROUND: The origin of collagen autoimmune diseases is not fully understood. Some studies postulate a mechanism of molecular mimicry or heterologous immunity following viral infections triggering autoimmunity. Apart from infections, other exogenous factors such as visible light or X-rays have been reported to incite autoimmunity.
CASE REPORT: We report a case of histologically and serologically confirmed subacute lupus erythematosus (SCLE) following radiotherapy for breast cancer.
DISCUSSION: The close temporal and spatial correlation between radiotherapy and onset of SCLE in this patient suggests that an autoimmune reaction may have been triggered locally by functionally altering the immune system and breaking self-tolerance.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Autoimmune reaction; Autoimmunity; Lupus erythematosus; Radiotherapy
Language:English
Date:2013
Deposited On:08 Jan 2014 07:28
Last Modified:08 Dec 2017 01:43
Publisher:Karger
ISSN:1662-6567
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1159/000354721
PubMed ID:24019776

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