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Massive uric acid nephrolithiasis with progressive renal failure due to spontaneous tumour lysis syndrome


Trachsler, J; Gaspert, A; Previsdomini, M; Wüthrich, R P; Fehr, T (2008). Massive uric acid nephrolithiasis with progressive renal failure due to spontaneous tumour lysis syndrome. NDT Plus, 5(1):307-309.

Abstract

Tumour lysis syndrome (TLS) is a constellation of metabolic
complications due to the rapid destruction of malignant
cells, causing renal, cardiac or cerebral dysfunction.
Electrolyte abnormalities include hyperuricaemia, hyperphosphataemia, hyperkalaemia and hypocalcaemia. TLSinduced renal failure is mainly caused by uric acid and
calcium phosphate crystal deposition and usually develops
following cytotoxic chemotherapy. Here, we present a case
of spontaneous TLS in a patient with chronic myelomonocytic
leukaemia (CMML) with massive uric acid stone and
crystal formation and rapidly worsening renal failure. Autopsy revealed underlying tumourous kidney infiltration.
Risk factors for occurrence of TLS and current therapeutic
management are discussed.

Abstract

Tumour lysis syndrome (TLS) is a constellation of metabolic
complications due to the rapid destruction of malignant
cells, causing renal, cardiac or cerebral dysfunction.
Electrolyte abnormalities include hyperuricaemia, hyperphosphataemia, hyperkalaemia and hypocalcaemia. TLSinduced renal failure is mainly caused by uric acid and
calcium phosphate crystal deposition and usually develops
following cytotoxic chemotherapy. Here, we present a case
of spontaneous TLS in a patient with chronic myelomonocytic
leukaemia (CMML) with massive uric acid stone and
crystal formation and rapidly worsening renal failure. Autopsy revealed underlying tumourous kidney infiltration.
Risk factors for occurrence of TLS and current therapeutic
management are discussed.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nephrology
04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2008
Deposited On:23 Dec 2008 08:34
Last Modified:05 Apr 2016 12:45
Publisher:Oxford University Press
ISSN:1753-0784
Publisher DOI:https://doi.org/10.1093/ndtplus/sfn133

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