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Transient severe non-proliferative retinopathy in an adolescent with type 1 diabetes and chronic myeloid leukemia


Schmid, Silvia; Lang-Muritano, Mariarosaria; Meier, Urs; De Peron, Riccardo; Konrad, Daniel; Schoenle, Eugen (2013). Transient severe non-proliferative retinopathy in an adolescent with type 1 diabetes and chronic myeloid leukemia. Pediatric Diabetes, 14(3):227-279.

Abstract

The onset of diabetic retinopathy correlates with the long-term quality of glycemic control. A 17-yr-old adolescent with type 1 diabetes presented unexpectedly with acute non-proliferative retinopathy despite good glycemic control. Two months later chronic myeloid leukemia (CML) was diagnosed. Chemotherapy was initiated and within a few weeks the patient was in full remission concerning leukemia. Retinopathy completely resolved within 8 months. The patient was in good metabolic control throughout the course. To our knowledge, this is the first report of CML-triggered retinopathy in a well-controlled diabetic adolescent. In case of unexpected retinopathy in patients with type 1 diabetes, other potential causes of retinopathy should be considered.

Abstract

The onset of diabetic retinopathy correlates with the long-term quality of glycemic control. A 17-yr-old adolescent with type 1 diabetes presented unexpectedly with acute non-proliferative retinopathy despite good glycemic control. Two months later chronic myeloid leukemia (CML) was diagnosed. Chemotherapy was initiated and within a few weeks the patient was in full remission concerning leukemia. Retinopathy completely resolved within 8 months. The patient was in good metabolic control throughout the course. To our knowledge, this is the first report of CML-triggered retinopathy in a well-controlled diabetic adolescent. In case of unexpected retinopathy in patients with type 1 diabetes, other potential causes of retinopathy should be considered.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:27 Jan 2014 15:53
Last Modified:07 Dec 2017 08:12
Publisher:Wiley-Blackwell
ISSN:1399-543X
Publisher DOI:https://doi.org/10.1111/j.1399-5448.2012.00901.x
PubMed ID:22817266

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