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Binding of a designed anti-cancer drug to the central cavity of an RNA three-way junction


Phongtongpasuk, S; Paulus, S; Schnabl, J; Sigel, Roland K O; Spingler, B; Hannon, M J; Freisinger, E (2013). Binding of a designed anti-cancer drug to the central cavity of an RNA three-way junction. Angewandte Chemie Internationale Edition, 52(44):11513-11516.

Abstract

Co-crystallization of an RNA three-way junction with a cylindrical di-iron(II)-based anti-cancer drug (green) results in π-stacking interactions between the cylinder and the central base pairs of the RNA structure. The shape, size, and cationic nature of the cylinder were found to be responsible for this perfect fit. Native gel electrophoresis studies confirmed stabilization of the RNA three-way junction by the iron(II) cylinder.

Abstract

Co-crystallization of an RNA three-way junction with a cylindrical di-iron(II)-based anti-cancer drug (green) results in π-stacking interactions between the cylinder and the central base pairs of the RNA structure. The shape, size, and cationic nature of the cylinder were found to be responsible for this perfect fit. Native gel electrophoresis studies confirmed stabilization of the RNA three-way junction by the iron(II) cylinder.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2013
Deposited On:03 Feb 2014 13:46
Last Modified:20 May 2017 07:08
Publisher:Wiley-VCH Verlag
ISSN:1433-7851
Publisher DOI:https://doi.org/10.1002/anie.201305079

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