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Synthesis, structure, physico-chemical and biological properties of metal(II) complexes with 5-amino-8-methyl-4H-benzopyran-4-one


Grazul, Magdalena; Sigel, Roland K O; Maake, Caroline; Besic-Gyenge, Emina; Lorenz, Ingo-Peter; Mayer, Peter; Czyz, Malgorzata; Budzisz, Elzbieta (2014). Synthesis, structure, physico-chemical and biological properties of metal(II) complexes with 5-amino-8-methyl-4H-benzopyran-4-one. Polyhedron, 67:136-144.

Abstract

Two new complexes of a previously obtained chromone derivative, 5-amino-8-methyl-4H-benzopyran-4-one (ligand 1), with the Co(II) (4) and Pd(II) (5) ions were synthesized and characterized by elemental analysis, IR and mass spectroscopy. The previously characterized Cu(II) complexes (2 and 3) and the newly obtained complexes of ligand 1 with Pd(II) and Co(II) have been tested as potential anticancer compounds. The molecular structure of 5 has been determined by X-ray crystallography. Biological properties, such as cytotoxicity against several cancer cell lines, the influence of the obtained compounds on the DNA structure by CD spectroscopy and agarose gel electrophoresis, have been evaluated. Also some physico-chemical properties, such as lipophilicity and stability in the aqueous solution, were tested.

Abstract

Two new complexes of a previously obtained chromone derivative, 5-amino-8-methyl-4H-benzopyran-4-one (ligand 1), with the Co(II) (4) and Pd(II) (5) ions were synthesized and characterized by elemental analysis, IR and mass spectroscopy. The previously characterized Cu(II) complexes (2 and 3) and the newly obtained complexes of ligand 1 with Pd(II) and Co(II) have been tested as potential anticancer compounds. The molecular structure of 5 has been determined by X-ray crystallography. Biological properties, such as cytotoxicity against several cancer cell lines, the influence of the obtained compounds on the DNA structure by CD spectroscopy and agarose gel electrophoresis, have been evaluated. Also some physico-chemical properties, such as lipophilicity and stability in the aqueous solution, were tested.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Anatomy
07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:8 January 2014
Deposited On:31 Jan 2014 13:50
Last Modified:07 Dec 2017 08:26
Publisher:Elsevier
ISSN:0277-5387
Publisher DOI:https://doi.org/10.1016/j.poly.2013.08.071

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