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LC3-associated phagocytosis


Romao, Susana; Münz, Christian (2014). LC3-associated phagocytosis. Autophagy, 10(3):ahead of print.

Abstract

A recent report from our group has described that upon engulfment of pathogens, a subset of phagosomes is formed to preserve antigens for prolonged presentation on MHC class II molecules. The distinctive feature of these particular vesicles is their coating with LC3/Atg8, a key component of the autophagy machinery. Here we discuss the possible outcomes of LC3-associated phagocytosis and its implications in the context of immunity.

Abstract

A recent report from our group has described that upon engulfment of pathogens, a subset of phagosomes is formed to preserve antigens for prolonged presentation on MHC class II molecules. The distinctive feature of these particular vesicles is their coating with LC3/Atg8, a key component of the autophagy machinery. Here we discuss the possible outcomes of LC3-associated phagocytosis and its implications in the context of immunity.

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23 citations in Web of Science®
24 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:2014
Deposited On:07 Mar 2014 16:20
Last Modified:05 Apr 2016 17:29
Publisher:Landes Bioscience
ISSN:1554-8627
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.4161/auto.27606
PubMed ID:24413059

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