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Giant primary retroperitoneal myxoid leiomyoma: a case report


Radojković, Milan; Stojanović, Miroslav; Gligorijevioć, Jasmina; Stanojević, Goran; Kovarevios, Predrag; Petković, Tatjana Radjenović; Pecić, Vanja; Rancić, Zoran (2013). Giant primary retroperitoneal myxoid leiomyoma: a case report. Vojnosanitetski Pregled, 70(5):522-526.

Abstract

INTRODUCTION: Leiomyomas are benign smooth muscle tumors that usually arise from the uterus.
CASE REPORT: We present a patient with a 6-month history of vague abdominal discomfort, occasional nausea, vomiting and urinary incontinence. On examination, there was an extremely large firm unpainfull palpable abdominal mass. Laboratory investigation revealed mild leukocytosis and blood creatinine elevation. Abdominopelvic ultrasonography and computed tomography revealed a massive well bordered, encapsulated intraabdominal tumor, extending from the pelvis to epigastrium and almost completely fulfilling the pelvic and abdominal cavity. At laparotomy, tumor arising from the retroperitoneum was excised in toto. Histopathological examination disclosed that the tumor was composed mainly of smooth muscle cells and very rare fibrous connective tissue elements with myxomatous alteration and with no mitotic activity. The negative results of numerous additional parameters analyzed (pancytokeratin, epithelial membrane antigen, S100 protein, CD68, CD34, desmin, aktin) ruled out different origin of a tumor. One year after resection the patient had no complaints and no radiological evidence of tumor recurrence.
CONCLUSION: Considering current limitations in radiological diagnosis, in toto resection of these tumors is necessary to rule out malignancy.

Abstract

INTRODUCTION: Leiomyomas are benign smooth muscle tumors that usually arise from the uterus.
CASE REPORT: We present a patient with a 6-month history of vague abdominal discomfort, occasional nausea, vomiting and urinary incontinence. On examination, there was an extremely large firm unpainfull palpable abdominal mass. Laboratory investigation revealed mild leukocytosis and blood creatinine elevation. Abdominopelvic ultrasonography and computed tomography revealed a massive well bordered, encapsulated intraabdominal tumor, extending from the pelvis to epigastrium and almost completely fulfilling the pelvic and abdominal cavity. At laparotomy, tumor arising from the retroperitoneum was excised in toto. Histopathological examination disclosed that the tumor was composed mainly of smooth muscle cells and very rare fibrous connective tissue elements with myxomatous alteration and with no mitotic activity. The negative results of numerous additional parameters analyzed (pancytokeratin, epithelial membrane antigen, S100 protein, CD68, CD34, desmin, aktin) ruled out different origin of a tumor. One year after resection the patient had no complaints and no radiological evidence of tumor recurrence.
CONCLUSION: Considering current limitations in radiological diagnosis, in toto resection of these tumors is necessary to rule out malignancy.

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Additional indexing

Other titles:Gigantski primarni retroperitonealni miksoidni lejomiom
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiovascular Surgery
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:2013
Deposited On:04 Feb 2014 08:12
Last Modified:05 Apr 2016 17:30
Publisher:Savezno Ministarstvo Odbrane * Sanitetska Uprava
ISSN:0042-8450
Publisher DOI:https://doi.org/10.2298/VSP1305522R
PubMed ID:23789294

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