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Fine-mapping at the HTR2A locus reveals multiple episodic memory-related variants


Sigmund, J C; Vogler, C; Huynh, K D; de Quervain, D J F; Papassotiropoulos, A (2008). Fine-mapping at the HTR2A locus reveals multiple episodic memory-related variants. Biological Psychology, 79(2):239-242.

Abstract

A functional polymorphism (His452Tyr) in the gene encoding the serotonin 2A receptor (HTR2A) has been previously associated with human episodic memory performance and with differences in brain volume in memory-related brain regions. Here we present data obtained through imputation and fine-mapping showing that multiple loci within HTR2A are significantly associated with human memory performance independently of the His452Tyr polymorphism. Our data support the existence of multiple memory-related loci within HTR2A.

Abstract

A functional polymorphism (His452Tyr) in the gene encoding the serotonin 2A receptor (HTR2A) has been previously associated with human episodic memory performance and with differences in brain volume in memory-related brain regions. Here we present data obtained through imputation and fine-mapping showing that multiple loci within HTR2A are significantly associated with human memory performance independently of the His452Tyr polymorphism. Our data support the existence of multiple memory-related loci within HTR2A.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:14 June 2008
Deposited On:30 Dec 2008 17:22
Last Modified:03 Sep 2016 07:09
Publisher:Elsevier
ISSN:0301-0511
Publisher DOI:https://doi.org/10.1016/j.biopsycho.2008.06.002
PubMed ID:18602445

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