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Toward a rational design of surface textures promoting Endothelialization


Potthoff, Eva; Franco, Davide; D'Alessandro, Valentina; Starck, Christoph; Falk, Volkmar; Zambelli, Tomaso; Vorholt, Julia A; Poulikakos, Dimos; Ferrari, Aldo (2014). Toward a rational design of surface textures promoting Endothelialization. Nano letters, 14(2):1069-1079.

Abstract

The safe integration of cardiovascular devices requires the sustainable coverage of their luminal surface by endothelial cells (ECs). The engineering of active surface textures has the potential to coordinate cellular adhesion and migration under the action of hemodynamic forces. We define a paradigm to rationally design textures maximizing EC activities as a function of the applied stresses. This is based on harnessing the adhesions established by ECs through fine-tuning of the vertical extend of the underlying surface nanotopography.

Abstract

The safe integration of cardiovascular devices requires the sustainable coverage of their luminal surface by endothelial cells (ECs). The engineering of active surface textures has the potential to coordinate cellular adhesion and migration under the action of hemodynamic forces. We define a paradigm to rationally design textures maximizing EC activities as a function of the applied stresses. This is based on harnessing the adhesions established by ECs through fine-tuning of the vertical extend of the underlying surface nanotopography.

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19 citations in Web of Science®
21 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiovascular Surgery
04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:German
Date:2014
Deposited On:17 Mar 2014 10:27
Last Modified:05 Apr 2016 17:34
Publisher:American Chemical Society
ISSN:1530-6984
Publisher DOI:https://doi.org/10.1021/nl4047398
PubMed ID:24428164

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