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Wirkmechanismen von Disulfiram und Behandlungsoptimierung in der Alkohol-Rückfallprophylaxe


Mutschler, Jochen; Kiefer, Falk (2013). Wirkmechanismen von Disulfiram und Behandlungsoptimierung in der Alkohol-Rückfallprophylaxe. Praxis, 102(3):139-146.

Abstract

The current frequent use of disulfiram in alcohol relapse prevention, and the possible extension of the indication (cocaine addiction, pathological gambling) make in-depth knowledge about therapeutic effects, interactions, contraindications, and side effects of disulfiram in alcohol relapse prevention the psychological-psychotherapeutic and supportive effects are perhaps more important than the pharmacological effects. The efficacy and safety of supervised disulfiram treatment is verified in a number of studies (also in co-morbid psychiatric patients). In addition, in this review options were presented, which can improve the safety of the treatment with disulfiram (e.g. Ethylglucuoronide and pharmacogenetics). Given the high prevalence of alcohol dependence in our view disulfiram is used very little, although the use of disulfiram in the context of structured, multi-modal outpatient treatment programs are considered to be safe.

Abstract

The current frequent use of disulfiram in alcohol relapse prevention, and the possible extension of the indication (cocaine addiction, pathological gambling) make in-depth knowledge about therapeutic effects, interactions, contraindications, and side effects of disulfiram in alcohol relapse prevention the psychological-psychotherapeutic and supportive effects are perhaps more important than the pharmacological effects. The efficacy and safety of supervised disulfiram treatment is verified in a number of studies (also in co-morbid psychiatric patients). In addition, in this review options were presented, which can improve the safety of the treatment with disulfiram (e.g. Ethylglucuoronide and pharmacogenetics). Given the high prevalence of alcohol dependence in our view disulfiram is used very little, although the use of disulfiram in the context of structured, multi-modal outpatient treatment programs are considered to be safe.

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Additional indexing

Other titles:Mechanism of action of disulfiram and treatment optimization in prevention of recurrent alcoholism
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:2013
Deposited On:17 Feb 2014 10:34
Last Modified:05 Apr 2016 17:34
Publisher:Hans Huber
ISSN:1661-8157
Publisher DOI:https://doi.org/10.1024/1661-8157/a001178
PubMed ID:23384983

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