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miR-30c-2-3p and miR-30a-3p: New pieces of the Jigsaw puzzle in HIF2α regulation


Moch, Holger; Lukamowicz-Rajska, Magdalena (2014). miR-30c-2-3p and miR-30a-3p: New pieces of the Jigsaw puzzle in HIF2α regulation. Cancer Discovery, 4(1):22-24.

Abstract

Summary: Clear cell renal cell carcinoma (ccRCC), the most frequent subtype of renal cell cancer, is characterized by mutation of the von Hippel-Lindau (VHL) tumor suppressor gene, which results in stabilization of hypoxia-inducible factor (HIF) α proteins. In this issue of Cancer Discovery, Mathew and colleagues report that miR-30c-2-3p and miR-30a-3p downregulation in ccRCC promotes increased expression of HIF2α.Cancer Discov; 4(1); 22-4. ©2014 AACR.

Abstract

Summary: Clear cell renal cell carcinoma (ccRCC), the most frequent subtype of renal cell cancer, is characterized by mutation of the von Hippel-Lindau (VHL) tumor suppressor gene, which results in stabilization of hypoxia-inducible factor (HIF) α proteins. In this issue of Cancer Discovery, Mathew and colleagues report that miR-30c-2-3p and miR-30a-3p downregulation in ccRCC promotes increased expression of HIF2α.Cancer Discov; 4(1); 22-4. ©2014 AACR.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2014
Deposited On:24 Mar 2014 13:58
Last Modified:08 Dec 2017 04:09
Publisher:American Association for Cancer Research
ISSN:2159-8274
Publisher DOI:https://doi.org/10.1158/2159-8290.CD-13-0897
PubMed ID:24402943

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