Header

UZH-Logo

Maintenance Infos

Bacterial Colitis Increases Susceptibility to Oral Prion Disease


Sigurdson, C J; Heikenwalder, M; Manco, G; Barthel, M; Schwarz, P; Stecher, B; Krautler, N J; Hardt, W D; Seifert, B; MacPherson, A J S; Corthesy, I; Aguzzi, A (2009). Bacterial Colitis Increases Susceptibility to Oral Prion Disease. Journal of Infectious Diseases, 199(2):243-252.

Abstract

Dietary exposure to prion-contaminated materials has caused kuru and variant Creutzfeldt-Jakob disease in humans and transmissible spongiform encephalopathies (TSEs) in cattle, mink, and felines. The epidemiology of dietary prion infections suggests that host genetic modifiers and possibly exogenous cofactors may play a decisive role in determining disease susceptibility. However, few cofactors influencing susceptibility to prion infection have been identified. In the present study, we investigated whether colitis might represent one such cofactor. We report that moderate colitis caused by an attenuated Salmonella strain more than doubles the susceptibility of mice to oral prion infection and modestly accelerates the development of disease after prion challenge. The prion protein was up-regulated in intestines and mesenteric lymph nodes of mice with colitis, providing a possible mechanism for the effect of colitis on the pathogenesis of prion disease. Therefore, moderate intestinal inflammation at the time of prion exposure may constitute one of the elusive risk factors underlying the development of TSE.

Abstract

Dietary exposure to prion-contaminated materials has caused kuru and variant Creutzfeldt-Jakob disease in humans and transmissible spongiform encephalopathies (TSEs) in cattle, mink, and felines. The epidemiology of dietary prion infections suggests that host genetic modifiers and possibly exogenous cofactors may play a decisive role in determining disease susceptibility. However, few cofactors influencing susceptibility to prion infection have been identified. In the present study, we investigated whether colitis might represent one such cofactor. We report that moderate colitis caused by an attenuated Salmonella strain more than doubles the susceptibility of mice to oral prion infection and modestly accelerates the development of disease after prion challenge. The prion protein was up-regulated in intestines and mesenteric lymph nodes of mice with colitis, providing a possible mechanism for the effect of colitis on the pathogenesis of prion disease. Therefore, moderate intestinal inflammation at the time of prion exposure may constitute one of the elusive risk factors underlying the development of TSE.

Statistics

Citations

21 citations in Web of Science®
20 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

106 downloads since deposited on 08 Jan 2009
15 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:08 Jan 2009 14:06
Last Modified:21 Nov 2017 13:46
Publisher:University of Chicago Press
ISSN:0022-1899
Additional Information:© 2008 by The Journal of Infectious Diseases.
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1086/595791
PubMed ID:19072552

Download

Download PDF  'Bacterial Colitis Increases Susceptibility to Oral Prion Disease'.
Preview
Filetype: PDF
Size: 1MB
View at publisher