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The cocktail approach and its utility in drug-drug interaction assessments for therapeutic proteins


Jetter, Alexander; Fuhr, Uwe (2013). The cocktail approach and its utility in drug-drug interaction assessments for therapeutic proteins. In: Zhou, H H; Meibohm, B. Drug-Drug Interaction Assessments for Therapeutic Proteins. Hoboken, NJ, USA: John Wiley & Sons, 111-118.

Abstract

This chapter demonstrates that the cocktail approach is suitable for the study of interactions between therapeutic proteins and drugs in humans—namely for the study of the effect of therapeutic proteins on cytochrome P450 enzyme activities.This is the area in which the FDA's current draft guideline on drug interaction studies recommends the use of cocktail phenotyping studies as an alternative to individual therapeutic protein–drug interaction studies.

Abstract

This chapter demonstrates that the cocktail approach is suitable for the study of interactions between therapeutic proteins and drugs in humans—namely for the study of the effect of therapeutic proteins on cytochrome P450 enzyme activities.This is the area in which the FDA's current draft guideline on drug interaction studies recommends the use of cocktail phenotyping studies as an alternative to individual therapeutic protein–drug interaction studies.

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Additional indexing

Item Type:Book Section, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:26 Feb 2014 12:21
Last Modified:05 Apr 2016 17:43
Publisher:John Wiley & Sons
ISBN:978-1-118-03216-9
Publisher DOI:https://doi.org/10.1002/9780470571224.pse478

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